Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs
Recently, pectin has been used as an alternative for commercial prebiotic products to modulate gut microbiota. In this study, the standard diet (Chow group) and high fat diet containing 0% (HF group), 1%, 3%, 5%, 8% or 12% (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week...
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000811 |
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| author | Yuanyuan Zhao Jinfeng Bi Jianyong Yi Jian Peng Qiancheng Ma |
| author_facet | Yuanyuan Zhao Jinfeng Bi Jianyong Yi Jian Peng Qiancheng Ma |
| author_sort | Yuanyuan Zhao |
| collection | DOAJ |
| description | Recently, pectin has been used as an alternative for commercial prebiotic products to modulate gut microbiota. In this study, the standard diet (Chow group) and high fat diet containing 0% (HF group), 1%, 3%, 5%, 8% or 12% (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week C57BL/6J mice (n = 10/group). Results showed that body weight gain (R2 = –0.990), subcutaneous adipose accumulation (R2 = –0.930), serum triglyceride elevation (R2 = –0.879), acetate (R2 = 0.955) and propionate concentration reduction (R2 = 0.985) were suppressed by pectin from 1% to 12%, indicating dose response to pectin consumption. Moreover, abundance of obesity-related bacteria Coriobacteriaceae, and pectin-degradating bacteria, Faecalibaculum, Ruminococcus were significantly increased with pectin dosage increased, and the R2 were 0.936, 0.963 and 0.937, respectively. Besides, attenuations for colonic injury and liver steatosis were observed after adding 5% and 8% pectin, respectively. This study confirmed the dose-sensitive manner of pectin to alleviate HF-induced obesity by modulating gut microbiota and enhancing short-chain fatty acids production. |
| format | Article |
| id | doaj-art-9fa3456ba8854fc1963827645cc78b28 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-9fa3456ba8854fc1963827645cc78b282025-02-03T06:51:25ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-01111143154Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAsYuanyuan Zhao0Jinfeng Bi1Jianyong Yi2Jian Peng3Qiancheng Ma4Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Corresponding authors at: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China.Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Corresponding authors at: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China.Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Sericultural and Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaRecently, pectin has been used as an alternative for commercial prebiotic products to modulate gut microbiota. In this study, the standard diet (Chow group) and high fat diet containing 0% (HF group), 1%, 3%, 5%, 8% or 12% (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week C57BL/6J mice (n = 10/group). Results showed that body weight gain (R2 = –0.990), subcutaneous adipose accumulation (R2 = –0.930), serum triglyceride elevation (R2 = –0.879), acetate (R2 = 0.955) and propionate concentration reduction (R2 = 0.985) were suppressed by pectin from 1% to 12%, indicating dose response to pectin consumption. Moreover, abundance of obesity-related bacteria Coriobacteriaceae, and pectin-degradating bacteria, Faecalibaculum, Ruminococcus were significantly increased with pectin dosage increased, and the R2 were 0.936, 0.963 and 0.937, respectively. Besides, attenuations for colonic injury and liver steatosis were observed after adding 5% and 8% pectin, respectively. This study confirmed the dose-sensitive manner of pectin to alleviate HF-induced obesity by modulating gut microbiota and enhancing short-chain fatty acids production.http://www.sciencedirect.com/science/article/pii/S2213453021000811PectinDosageObesityGut microbiotaShort-chain fatty acid |
| spellingShingle | Yuanyuan Zhao Jinfeng Bi Jianyong Yi Jian Peng Qiancheng Ma Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs Food Science and Human Wellness Pectin Dosage Obesity Gut microbiota Short-chain fatty acid |
| title | Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs |
| title_full | Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs |
| title_fullStr | Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs |
| title_full_unstemmed | Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs |
| title_short | Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs |
| title_sort | dose dependent effects of apple pectin on alleviating high fat induced obesity modulated by gut microbiota and scfas |
| topic | Pectin Dosage Obesity Gut microbiota Short-chain fatty acid |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000811 |
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