Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most stu...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/891020 |
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| _version_ | 1832547242372759552 |
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| author | Marina Okuyama Kishima Carlos Eduardo Coral de Oliveira Bruna Karina Banin-Hirata Roberta Losi-Guembarovski Karen Brajão de Oliveira Marla Karine Amarante Maria Angelica Ehara Watanabe |
| author_facet | Marina Okuyama Kishima Carlos Eduardo Coral de Oliveira Bruna Karina Banin-Hirata Roberta Losi-Guembarovski Karen Brajão de Oliveira Marla Karine Amarante Maria Angelica Ehara Watanabe |
| author_sort | Marina Okuyama Kishima |
| collection | DOAJ |
| description | Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance. |
| format | Article |
| id | doaj-art-9fa0bfe3f6604b17a19e84a059a7634f |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-9fa0bfe3f6604b17a19e84a059a7634f2025-02-03T06:45:28ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/891020891020Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical SignificanceMarina Okuyama Kishima0Carlos Eduardo Coral de Oliveira1Bruna Karina Banin-Hirata2Roberta Losi-Guembarovski3Karen Brajão de Oliveira4Marla Karine Amarante5Maria Angelica Ehara Watanabe6Laboratory of Human Pathology, Department of Pathology, Clinical Analysis and Toxicology, Health Sciences Center, University Hospital of Londrina, State University of Londrina, 86038-350 Londrina, PR, BrazilLaboratory of Study and Application of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057-970 Londrina, PR, BrazilLaboratory of Study and Application of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057-970 Londrina, PR, BrazilLaboratory of Study and Application of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057-970 Londrina, PR, BrazilLaboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057-970 Londrina, PR, BrazilLaboratory of Study and Application of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057-970 Londrina, PR, BrazilLaboratory of Study and Application of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057-970 Londrina, PR, BrazilMany tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance.http://dx.doi.org/10.1155/2015/891020 |
| spellingShingle | Marina Okuyama Kishima Carlos Eduardo Coral de Oliveira Bruna Karina Banin-Hirata Roberta Losi-Guembarovski Karen Brajão de Oliveira Marla Karine Amarante Maria Angelica Ehara Watanabe Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance Analytical Cellular Pathology |
| title | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
| title_full | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
| title_fullStr | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
| title_full_unstemmed | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
| title_short | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
| title_sort | immunohistochemical expression of cxcr4 on breast cancer and its clinical significance |
| url | http://dx.doi.org/10.1155/2015/891020 |
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