Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis
A 17-year-old boy with juvenile dermatomyositis presented with typical skin symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle symptoms responded to treatment with prednisolone and azathioprine. However, calcinosis did not improve, and the patient had a limited range o...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2015/817592 |
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| author | Takayuki Wakabayashi Noriko Sasaki Naofumi Chinen Yasuo Suzuki |
| author_facet | Takayuki Wakabayashi Noriko Sasaki Naofumi Chinen Yasuo Suzuki |
| author_sort | Takayuki Wakabayashi |
| collection | DOAJ |
| description | A 17-year-old boy with juvenile dermatomyositis presented with typical skin symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle symptoms responded to treatment with prednisolone and azathioprine. However, calcinosis did not improve, and the patient had a limited range of knee joint motion and resultant disturbance of daily activities. Cimetidine was combined with intermittent administration of high-dose etidronate, leading to marked improvement of both subcutaneous and muscular calcinosis with no skeletal adverse reactions during a long treatment period exceeding 5 years. As a result, the range of knee joint motion has increased and performance of daily activities has improved. |
| format | Article |
| id | doaj-art-9f9eed20b8984706a46af4f0f71c6c89 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-9f9eed20b8984706a46af4f0f71c6c892025-02-03T00:59:31ZengWileyCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/817592817592Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile DermatomyositisTakayuki Wakabayashi0Noriko Sasaki1Naofumi Chinen2Yasuo Suzuki3Department of Rheumatology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji 192-0032, JapanDepartment of Rheumatology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji 192-0032, JapanDivision of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, JapanDivision of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, JapanA 17-year-old boy with juvenile dermatomyositis presented with typical skin symptoms, mild myositis, and bilateral lower limb calcinosis. His skin and muscle symptoms responded to treatment with prednisolone and azathioprine. However, calcinosis did not improve, and the patient had a limited range of knee joint motion and resultant disturbance of daily activities. Cimetidine was combined with intermittent administration of high-dose etidronate, leading to marked improvement of both subcutaneous and muscular calcinosis with no skeletal adverse reactions during a long treatment period exceeding 5 years. As a result, the range of knee joint motion has increased and performance of daily activities has improved.http://dx.doi.org/10.1155/2015/817592 |
| spellingShingle | Takayuki Wakabayashi Noriko Sasaki Naofumi Chinen Yasuo Suzuki Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis Case Reports in Rheumatology |
| title | Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis |
| title_full | Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis |
| title_fullStr | Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis |
| title_full_unstemmed | Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis |
| title_short | Dramatic Improvement of Subcutaneous Calcinosis by Intermittent, High-Dose Etidronate plus Cimetidine in a Patient with Juvenile Dermatomyositis |
| title_sort | dramatic improvement of subcutaneous calcinosis by intermittent high dose etidronate plus cimetidine in a patient with juvenile dermatomyositis |
| url | http://dx.doi.org/10.1155/2015/817592 |
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