Behçet's Disease (Adamantiades-Behçet's Disease)
Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction agai...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/681956 |
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| author | Fumio Kaneko Ari Togashi Sanae Saito Hideo Sakuma Noritaka Oyama Koichiro Nakamura Kenji Yokota Keiji Oguma |
| author_facet | Fumio Kaneko Ari Togashi Sanae Saito Hideo Sakuma Noritaka Oyama Koichiro Nakamura Kenji Yokota Keiji Oguma |
| author_sort | Fumio Kaneko |
| collection | DOAJ |
| description | Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage. |
| format | Article |
| id | doaj-art-9f7b7eca2db94f88b9a7e06c09585856 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9f7b7eca2db94f88b9a7e06c095858562025-02-03T06:11:39ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/681956681956Behçet's Disease (Adamantiades-Behçet's Disease)Fumio Kaneko0Ari Togashi1Sanae Saito2Hideo Sakuma3Noritaka Oyama4Koichiro Nakamura5Kenji Yokota6Keiji Oguma7Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, JapanInstitute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, JapanInstitute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, JapanPathology Division, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama 963-8563, JapanDepartments of Dermatology, School of Medicine, Fukushima Medical University, Hikarigaoka-1, Fukushima 960-1295, JapanSaitama Medical University, 38 Hongo, Moroyama, Iruma-gun, Saitama 350-0495, JapanDepartment of Bacteriology, Graduate School of Medicine and Dentistry, Medical School, Okayama University, 5-1, Shikata-cho-2, Okayama 700-8558, JapanDepartment of Bacteriology, Graduate School of Medicine and Dentistry, Medical School, Okayama University, 5-1, Shikata-cho-2, Okayama 700-8558, JapanAdamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.http://dx.doi.org/10.1155/2011/681956 |
| spellingShingle | Fumio Kaneko Ari Togashi Sanae Saito Hideo Sakuma Noritaka Oyama Koichiro Nakamura Kenji Yokota Keiji Oguma Behçet's Disease (Adamantiades-Behçet's Disease) Clinical and Developmental Immunology |
| title | Behçet's Disease (Adamantiades-Behçet's Disease) |
| title_full | Behçet's Disease (Adamantiades-Behçet's Disease) |
| title_fullStr | Behçet's Disease (Adamantiades-Behçet's Disease) |
| title_full_unstemmed | Behçet's Disease (Adamantiades-Behçet's Disease) |
| title_short | Behçet's Disease (Adamantiades-Behçet's Disease) |
| title_sort | behcet s disease adamantiades behcet s disease |
| url | http://dx.doi.org/10.1155/2011/681956 |
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