Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report
Herein, we report a case of allergic bronchopulmonary aspergillosis (ABPA) complicated by Strongyloides stercoralis infection. A 73-year-old man with a history of duodenal ulcer perforation and prior Billroth II gastrectomy presented with a 14-year history of recurrent cough and wheezing, recently a...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1591707/full |
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| author | Zhuangheng Lin Weiming Su Dinghui Wu Yangkun Lin Lijuan Jian Zigang He Dandan Jiang |
| author_facet | Zhuangheng Lin Weiming Su Dinghui Wu Yangkun Lin Lijuan Jian Zigang He Dandan Jiang |
| author_sort | Zhuangheng Lin |
| collection | DOAJ |
| description | Herein, we report a case of allergic bronchopulmonary aspergillosis (ABPA) complicated by Strongyloides stercoralis infection. A 73-year-old man with a history of duodenal ulcer perforation and prior Billroth II gastrectomy presented with a 14-year history of recurrent cough and wheezing, recently accompanied by new gastrointestinal symptoms. He was initially diagnosed with chronic obstructive pulmonary disease (COPD). Subsequent laboratory evaluation revealed a markedly elevated total serum IgE (1,219 kUA/L) and increased Aspergillus fumigatus-specific IgE (0.38 kUA/L, positive cutoff >0.35 kUA/L), leading to a diagnosis of ABPA. Despite antifungal and corticosteroid therapy, total IgE levels remained persistently elevated, accompanied by worsening gastrointestinal symptoms. Multiple stool examinations failed to detect parasitic infection. As gastrointestinal symptoms progressed, gastroscopy revealed the presence of parasitic eggs and larvae. Subsequently, a stool specimen was sent to the Xiamen Center for Disease Control and Prevention. Using the formol-ether concentration technique, the microscopic examination ultimately confirmed an infection with Strongyloides stercoralis. Following albendazole treatment, the patient’s symptoms completely resolved. In conclusion, co-infection of ABPA with Strongyloides stercoralis may lead to missed or delayed diagnosis due to persistently elevated IgE levels. |
| format | Article |
| id | doaj-art-9f77dc89adfc41ff88f11995e274c94e |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-9f77dc89adfc41ff88f11995e274c94e2025-08-20T02:46:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15917071591707Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case reportZhuangheng LinWeiming SuDinghui WuYangkun LinLijuan JianZigang HeDandan JiangHerein, we report a case of allergic bronchopulmonary aspergillosis (ABPA) complicated by Strongyloides stercoralis infection. A 73-year-old man with a history of duodenal ulcer perforation and prior Billroth II gastrectomy presented with a 14-year history of recurrent cough and wheezing, recently accompanied by new gastrointestinal symptoms. He was initially diagnosed with chronic obstructive pulmonary disease (COPD). Subsequent laboratory evaluation revealed a markedly elevated total serum IgE (1,219 kUA/L) and increased Aspergillus fumigatus-specific IgE (0.38 kUA/L, positive cutoff >0.35 kUA/L), leading to a diagnosis of ABPA. Despite antifungal and corticosteroid therapy, total IgE levels remained persistently elevated, accompanied by worsening gastrointestinal symptoms. Multiple stool examinations failed to detect parasitic infection. As gastrointestinal symptoms progressed, gastroscopy revealed the presence of parasitic eggs and larvae. Subsequently, a stool specimen was sent to the Xiamen Center for Disease Control and Prevention. Using the formol-ether concentration technique, the microscopic examination ultimately confirmed an infection with Strongyloides stercoralis. Following albendazole treatment, the patient’s symptoms completely resolved. In conclusion, co-infection of ABPA with Strongyloides stercoralis may lead to missed or delayed diagnosis due to persistently elevated IgE levels.https://www.frontiersin.org/articles/10.3389/fmed.2025.1591707/fullStrongyloides stercoralis (S. stercoralis)allergic bronchopulmonary aspergillosis (ABPA)elevated IgEparasitic infectionscase report |
| spellingShingle | Zhuangheng Lin Weiming Su Dinghui Wu Yangkun Lin Lijuan Jian Zigang He Dandan Jiang Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report Frontiers in Medicine Strongyloides stercoralis (S. stercoralis) allergic bronchopulmonary aspergillosis (ABPA) elevated IgE parasitic infections case report |
| title | Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report |
| title_full | Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report |
| title_fullStr | Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report |
| title_full_unstemmed | Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report |
| title_short | Concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis: case report |
| title_sort | concurrent strongyloidiasis and allergic bronchopulmonary aspergillosis complicating diagnosis case report |
| topic | Strongyloides stercoralis (S. stercoralis) allergic bronchopulmonary aspergillosis (ABPA) elevated IgE parasitic infections case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1591707/full |
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