THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE
14 children with various clinical forms of steroid-resistant nephrotic syndrome have been examined to assess the efficacy of pharmacological blocking of RAAS using inhibitors of angiotensin-converting enzyme and Angiotensin II receptor blockers. While assessing the efficacy of the nephroprotective t...
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| Format: | Article |
| Language: | Russian |
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Union of pediatricians of Russia
2010-03-01
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| Series: | Педиатрическая фармакология |
| Online Access: | https://www.pedpharma.ru/jour/article/view/1178 |
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| author | E.S. Otroshchenko L.V. Leonova O.V. Komarova A.G. Timofeeva A.N. Tsygin |
| author_facet | E.S. Otroshchenko L.V. Leonova O.V. Komarova A.G. Timofeeva A.N. Tsygin |
| author_sort | E.S. Otroshchenko |
| collection | DOAJ |
| description | 14 children with various clinical forms of steroid-resistant nephrotic syndrome have been examined to assess the efficacy of pharmacological blocking of RAAS using inhibitors of angiotensin-converting enzyme and Angiotensin II receptor blockers. While assessing the efficacy of the nephroprotective therapy, the following was found in all the children: a reliably meaningful 1,5 times reduction ((р = 0,013) in the daily proteinuria level in 3 to 6 months, and by the end of the study — a 2,5 times reduction (р = 0,001) and improvement in the renal filtration function metrics in 3 to 6 months (р = 0,001), in 1 year (р = 0,013) and by the end of the study (p = 0,002) in comparison with the metrics prior to the launch of the nephroprotective therapy. Key words: chronic renal disease, proteinuria, RAAS, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers. (Pediatric Pharmacology. – 2010; 7(2):105-109) |
| format | Article |
| id | doaj-art-9f6535dfcd084dca8c639f92ce5df7cf |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2010-03-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-9f6535dfcd084dca8c639f92ce5df7cf2025-08-20T03:19:41ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892010-03-01721051091173THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASEE.S. Otroshchenko0L.V. Leonova1O.V. Komarova2A.G. Timofeeva3A.N. Tsygin4Scientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowRussian State Medical University, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow14 children with various clinical forms of steroid-resistant nephrotic syndrome have been examined to assess the efficacy of pharmacological blocking of RAAS using inhibitors of angiotensin-converting enzyme and Angiotensin II receptor blockers. While assessing the efficacy of the nephroprotective therapy, the following was found in all the children: a reliably meaningful 1,5 times reduction ((р = 0,013) in the daily proteinuria level in 3 to 6 months, and by the end of the study — a 2,5 times reduction (р = 0,001) and improvement in the renal filtration function metrics in 3 to 6 months (р = 0,001), in 1 year (р = 0,013) and by the end of the study (p = 0,002) in comparison with the metrics prior to the launch of the nephroprotective therapy. Key words: chronic renal disease, proteinuria, RAAS, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers. (Pediatric Pharmacology. – 2010; 7(2):105-109)https://www.pedpharma.ru/jour/article/view/1178 |
| spellingShingle | E.S. Otroshchenko L.V. Leonova O.V. Komarova A.G. Timofeeva A.N. Tsygin THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE Педиатрическая фармакология |
| title | THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE |
| title_full | THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE |
| title_fullStr | THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE |
| title_full_unstemmed | THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE |
| title_short | THE EFFICACY OF COMBINED PHARMACOLOGICAL BLOCKING OF RAAS IN CHILDREN WITH CHRONIC RENAL DISEASE |
| title_sort | efficacy of combined pharmacological blocking of raas in children with chronic renal disease |
| url | https://www.pedpharma.ru/jour/article/view/1178 |
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