The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions

The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions

In this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotti...

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Main Authors: Gulbarchyn Alisherovna Asrankulova, Zhyldyz Akmatovna Makhmudova, Mahira Rysbaevna Mirzaeva, Meerim Taalaibekovna Taalaibekova, Zyinat Samidinovna Boronova, Mairambu Bektemirovna Zhorobekova
Format: Article
Language:English
Published: EDP Sciences 2025-01-01
Series:E3S Web of Conferences
Subjects:
high altitude
old rats
oxidative stress
hemostasis
coenzyme q10
Online Access:https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03003.pdf
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Summary:In this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotting time and improved platelet aggregation parameters in old rats under low- and high-altitude conditions. In particular, a decrease in prothrombin time, prothrombin index, thrombin time and activated partial thromboplastin time, and a decrease in ADP concentration in old rats were observed. Consequently, the obtained results indicate the hypocoagulant effect of coenzyme Q10 in the hemostasis system in old rats.
ISSN:2267-1242

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