Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure
Background and Aims. The value of alpha-fetoprotein (AFP) in hepatitis B-related acute-on-chronic liver failure (HBACLF) is not fully understood. The present study aimed to evaluate the prognostic effect of AFP on the prediction of HBACLF outcomes. Methods. We investigated a cohort of patients with...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/1232785 |
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| _version_ | 1832551478463561728 |
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| author | Xiaoping Wang Caifei Shen Jianjiang Yang Xianjun Yang Sen Qin Haijun Zeng Xiaoling Wu Shanhong Tang Weizheng Zeng |
| author_facet | Xiaoping Wang Caifei Shen Jianjiang Yang Xianjun Yang Sen Qin Haijun Zeng Xiaoling Wu Shanhong Tang Weizheng Zeng |
| author_sort | Xiaoping Wang |
| collection | DOAJ |
| description | Background and Aims. The value of alpha-fetoprotein (AFP) in hepatitis B-related acute-on-chronic liver failure (HBACLF) is not fully understood. The present study aimed to evaluate the prognostic effect of AFP on the prediction of HBACLF outcomes. Methods. We investigated a cohort of patients with HBACLF admitted from January 2013 to May 2017. The endpoint of followup was 180 days, death, or liver transplantation. AFP concentrations were estimated on admission. To make statistical comparisons, we used chi-squared test, receiver operating characteristic (ROC) curve analysis, survivorship curve analysis, and Cox proportional-hazards model. Results. A total of 92 patients (81.5% male, median age of 46 years) were included. Overall survival rate within 180 days was 43.48%, and the value of log10AFP ≥ 2.04 indicated a better prognosis with 76.9% specificity and 62.5% sensitivity for patients with HBACLF. Age (HR 1.041), total bilirubin (HR 1.004), log10AFP (HR 2.155), and INR (HR 1.446) were found to be risk factors of survival. Conclusion. AFP could be a useful marker to predict outcomes of acute-on-chronic liver failure. |
| format | Article |
| id | doaj-art-9f5c82c188a248bcb27b748b8fec438f |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-9f5c82c188a248bcb27b748b8fec438f2025-02-03T06:01:21ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/12327851232785Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver FailureXiaoping Wang0Caifei Shen1Jianjiang Yang2Xianjun Yang3Sen Qin4Haijun Zeng5Xiaoling Wu6Shanhong Tang7Weizheng Zeng8Department of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaChengdu Military Command Disease Prevention and Control Center, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, ChinaBackground and Aims. The value of alpha-fetoprotein (AFP) in hepatitis B-related acute-on-chronic liver failure (HBACLF) is not fully understood. The present study aimed to evaluate the prognostic effect of AFP on the prediction of HBACLF outcomes. Methods. We investigated a cohort of patients with HBACLF admitted from January 2013 to May 2017. The endpoint of followup was 180 days, death, or liver transplantation. AFP concentrations were estimated on admission. To make statistical comparisons, we used chi-squared test, receiver operating characteristic (ROC) curve analysis, survivorship curve analysis, and Cox proportional-hazards model. Results. A total of 92 patients (81.5% male, median age of 46 years) were included. Overall survival rate within 180 days was 43.48%, and the value of log10AFP ≥ 2.04 indicated a better prognosis with 76.9% specificity and 62.5% sensitivity for patients with HBACLF. Age (HR 1.041), total bilirubin (HR 1.004), log10AFP (HR 2.155), and INR (HR 1.446) were found to be risk factors of survival. Conclusion. AFP could be a useful marker to predict outcomes of acute-on-chronic liver failure.http://dx.doi.org/10.1155/2018/1232785 |
| spellingShingle | Xiaoping Wang Caifei Shen Jianjiang Yang Xianjun Yang Sen Qin Haijun Zeng Xiaoling Wu Shanhong Tang Weizheng Zeng Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure Canadian Journal of Gastroenterology and Hepatology |
| title | Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure |
| title_full | Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure |
| title_fullStr | Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure |
| title_full_unstemmed | Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure |
| title_short | Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure |
| title_sort | alpha fetoprotein as a predictive marker for patients with hepatitis b related acute on chronic liver failure |
| url | http://dx.doi.org/10.1155/2018/1232785 |
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