Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn
Objective: To compare milrinone with sildenafil for the treatment of persistent pulmonary hypertension of the newborn. Methodology: A single blinded randomized control trial was conducted in Department of Pediatrics, Aziz Fatima Hospital Faisalabad from October 2022 to September 2023. 160 infan...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Aziz Fatimah Medical and Dental College
2024-06-01
|
| Series: | Journal of Aziz Fatimah Medical and Dental College |
| Subjects: | |
| Online Access: | https://journal.afmdc.edu.pk/index.php/AFMDC/article/view/285 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586145211351040 |
|---|---|
| author | Imtiaz Ahmad Motia Javaid Tanveer Ahmad Imran Baloch Nisar Khan Sajid Abdul Razzaq Mughal |
| author_facet | Imtiaz Ahmad Motia Javaid Tanveer Ahmad Imran Baloch Nisar Khan Sajid Abdul Razzaq Mughal |
| author_sort | Imtiaz Ahmad |
| collection | DOAJ |
| description |
Objective: To compare milrinone with sildenafil for the treatment of persistent pulmonary hypertension of the newborn.
Methodology: A single blinded randomized control trial was conducted in Department of Pediatrics, Aziz Fatima Hospital Faisalabad from October 2022 to September 2023. 160 infants of persistent pulmonary hypertension were included through non probablity consecutive sampling. Group 1 infants (n = 80) received a loading dose of milrinone intravenously administered over a 60-minute period at a dose of 50 µg/kg. Group 2 infants (n = 80) received sildenafil (2mg per kg per dose three times a day). The medication was continued until extubation. The primary outcome variables were the mortality and duration of hospital stay.
Results: Ninety two(57.5%) of the one hubdred & sixty newborns in total were male. 111(69.4%) of the total, were full-term babies. In 114(71.2%) infants, the mode of delivery was C-section. Mortality was observed in 7 (8.8%) patients in milrinone group and 17 (21.2%) patients in sildenafil group with p-value = 0.027. Duration of hospital stay was less in milrinone group as compared to sildenafil group (14.22±3.75 days vs 17.72±5.7 days) with p-value = 0.0001.
Conclusion: Milrinone has been proven to be a promising therapeutic choice for persistent pulmonary hypertension in neonates, and it is effective in doing so in low resource settings.
|
| format | Article |
| id | doaj-art-9f4c23ef349f4306a3e46ca81775f6ba |
| institution | Kabale University |
| issn | 2706-7238 2706-7246 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Aziz Fatimah Medical and Dental College |
| record_format | Article |
| series | Journal of Aziz Fatimah Medical and Dental College |
| spelling | doaj-art-9f4c23ef349f4306a3e46ca81775f6ba2025-01-26T08:46:02ZengAziz Fatimah Medical and Dental CollegeJournal of Aziz Fatimah Medical and Dental College2706-72382706-72462024-06-016110.55279/jafmdc.v6i1.285Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the NewbornImtiaz AhmadMotia Javaid Tanveer Ahmad Imran Baloch Nisar Khan Sajid Abdul Razzaq Mughal Objective: To compare milrinone with sildenafil for the treatment of persistent pulmonary hypertension of the newborn. Methodology: A single blinded randomized control trial was conducted in Department of Pediatrics, Aziz Fatima Hospital Faisalabad from October 2022 to September 2023. 160 infants of persistent pulmonary hypertension were included through non probablity consecutive sampling. Group 1 infants (n = 80) received a loading dose of milrinone intravenously administered over a 60-minute period at a dose of 50 µg/kg. Group 2 infants (n = 80) received sildenafil (2mg per kg per dose three times a day). The medication was continued until extubation. The primary outcome variables were the mortality and duration of hospital stay. Results: Ninety two(57.5%) of the one hubdred & sixty newborns in total were male. 111(69.4%) of the total, were full-term babies. In 114(71.2%) infants, the mode of delivery was C-section. Mortality was observed in 7 (8.8%) patients in milrinone group and 17 (21.2%) patients in sildenafil group with p-value = 0.027. Duration of hospital stay was less in milrinone group as compared to sildenafil group (14.22±3.75 days vs 17.72±5.7 days) with p-value = 0.0001. Conclusion: Milrinone has been proven to be a promising therapeutic choice for persistent pulmonary hypertension in neonates, and it is effective in doing so in low resource settings. https://journal.afmdc.edu.pk/index.php/AFMDC/article/view/285Persistent Pulmonary HypertensionMilirinoneSildenafilMortalityNewborn |
| spellingShingle | Imtiaz Ahmad Motia Javaid Tanveer Ahmad Imran Baloch Nisar Khan Sajid Abdul Razzaq Mughal Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn Journal of Aziz Fatimah Medical and Dental College Persistent Pulmonary Hypertension Milirinone Sildenafil Mortality Newborn |
| title | Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn |
| title_full | Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn |
| title_fullStr | Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn |
| title_full_unstemmed | Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn |
| title_short | Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn |
| title_sort | comparison of milrinone with sildenafil for the treatment of persistent pulmonary hypertension of the newborn |
| topic | Persistent Pulmonary Hypertension Milirinone Sildenafil Mortality Newborn |
| url | https://journal.afmdc.edu.pk/index.php/AFMDC/article/view/285 |
| work_keys_str_mv | AT imtiazahmad comparisonofmilrinonewithsildenafilforthetreatmentofpersistentpulmonaryhypertensionofthenewborn AT motiajavaid comparisonofmilrinonewithsildenafilforthetreatmentofpersistentpulmonaryhypertensionofthenewborn AT tanveerahmad comparisonofmilrinonewithsildenafilforthetreatmentofpersistentpulmonaryhypertensionofthenewborn AT imranbaloch comparisonofmilrinonewithsildenafilforthetreatmentofpersistentpulmonaryhypertensionofthenewborn AT nisarkhansajid comparisonofmilrinonewithsildenafilforthetreatmentofpersistentpulmonaryhypertensionofthenewborn AT abdulrazzaqmughal comparisonofmilrinonewithsildenafilforthetreatmentofpersistentpulmonaryhypertensionofthenewborn |