Nerve Growth Factor Modulates Regulatory Cell Volume Behavior via Stimulating TRPV1, TRPM8 Channels and Inducing Ca<sup>2+</sup> Signaling in Human Conjunctival Epithelial Cells

Nerve Growth Factor Modulates Regulatory Cell Volume Behavior via Stimulating TRPV1, TRPM8 Channels and Inducing Ca<sup>2+</sup> Signaling in Human Conjunctival Epithelial Cells

NGF plays important roles in ocular surface homeostasis and different pathological conditions. One effect includes promoting conjunctival epithelial cell differentiation and mucin secretion. This study characterizes the individual roles of TRPV1 and TRPM8 channel activity in mediating the effects of...

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Bibliographic Details
Main Authors: Friedrich Wolf, Tina Dietrich-Ntoukas, Peter S. Reinach, Uwe Pleyer, Stefan Mergler
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
nerve growth factor
TRPV 1
TRPM 8
conjunctival epithelial cells
Ca<sup>2+</sup> regulation
Online Access:https://www.mdpi.com/2073-4409/14/10/719
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