Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value
Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with G...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2017/2371956 |
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| author | Elyar Sadeghi-Hokmabadi Demet Funda Baş Mehdi Farhoudi Aliakbar Taheraghdam Daryoush Savadi Oskouei Mohammad Yazdchi Maziyar Hashemilar Nevzat Uzuner Reshad Mirnour Ertugrul Colak Atilla Özcan Özdemir |
| author_facet | Elyar Sadeghi-Hokmabadi Demet Funda Baş Mehdi Farhoudi Aliakbar Taheraghdam Daryoush Savadi Oskouei Mohammad Yazdchi Maziyar Hashemilar Nevzat Uzuner Reshad Mirnour Ertugrul Colak Atilla Özcan Özdemir |
| author_sort | Elyar Sadeghi-Hokmabadi |
| collection | DOAJ |
| description | Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2 and (2) low GFR group with GFR < 45 mL/min/1.73 m2. Outcome measurements were poor outcome (mRS 3–6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24–36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs). Results. Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09–1.30, p<0.001) and mortality (OR 1.18, 95% CI 1.06–1.32, p=0.002). In multivariate regression, adjusted for all variables with p value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01–4.56, p=0.045). Conclusion. In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2. |
| format | Article |
| id | doaj-art-9f45994dfbb34c399a28164a58be08eb |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-9f45994dfbb34c399a28164a58be08eb2025-02-03T05:45:44ZengWileyStroke Research and Treatment2090-81052042-00562017-01-01201710.1155/2017/23719562371956Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff ValueElyar Sadeghi-Hokmabadi0Demet Funda Baş1Mehdi Farhoudi2Aliakbar Taheraghdam3Daryoush Savadi Oskouei4Mohammad Yazdchi5Maziyar Hashemilar6Nevzat Uzuner7Reshad Mirnour8Ertugrul Colak9Atilla Özcan Özdemir10Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, TurkeyDepartment of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, TurkeyDepartment of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Neurology, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, TurkeyDepartment of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Biostatistics, Eskisehir Osmangazi University, Eskisehir, TurkeyDepartment of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, TurkeyObjective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2 and (2) low GFR group with GFR < 45 mL/min/1.73 m2. Outcome measurements were poor outcome (mRS 3–6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24–36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs). Results. Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09–1.30, p<0.001) and mortality (OR 1.18, 95% CI 1.06–1.32, p=0.002). In multivariate regression, adjusted for all variables with p value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01–4.56, p=0.045). Conclusion. In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2.http://dx.doi.org/10.1155/2017/2371956 |
| spellingShingle | Elyar Sadeghi-Hokmabadi Demet Funda Baş Mehdi Farhoudi Aliakbar Taheraghdam Daryoush Savadi Oskouei Mohammad Yazdchi Maziyar Hashemilar Nevzat Uzuner Reshad Mirnour Ertugrul Colak Atilla Özcan Özdemir Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value Stroke Research and Treatment |
| title | Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value |
| title_full | Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value |
| title_fullStr | Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value |
| title_full_unstemmed | Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value |
| title_short | Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value |
| title_sort | renal dysfunction is an independent risk factor for poor outcome in acute ischemic stroke patients treated with intravenous thrombolysis a new cutoff value |
| url | http://dx.doi.org/10.1155/2017/2371956 |
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