Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes
Growing evidence suggests that cancer should not be viewed solely as a genetic disease but also as the result of functional defects in the metaorganism, including disturbances in the gut microbiota (i.e., gut dysbiosis). The human microbiota plays a critical role in regulating epithelial barrier fun...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/504 |
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| author | Carolina Alves Costa Silva Andrew A. Almonte Laurence Zitvogel |
| author_facet | Carolina Alves Costa Silva Andrew A. Almonte Laurence Zitvogel |
| author_sort | Carolina Alves Costa Silva |
| collection | DOAJ |
| description | Growing evidence suggests that cancer should not be viewed solely as a genetic disease but also as the result of functional defects in the metaorganism, including disturbances in the gut microbiota (i.e., gut dysbiosis). The human microbiota plays a critical role in regulating epithelial barrier function in the gut, airways, and skin, along with host metabolism and systemic immune responses against microbes and cancer. Collaborative international networks, such as ONCOBIOME, are essential in advancing research equity and building microbiome resources to identify and validate microbiota-related biomarkers and therapies. In this review, we explore the intricate relationship between the microbiome, metabolism, and cancer immunity, and we propose microbiota-based strategies to improve outcomes for individuals at risk of developing cancer or living with the disease. |
| format | Article |
| id | doaj-art-9f3de1ef6f4247bca18f9a5f597598f0 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-9f3de1ef6f4247bca18f9a5f597598f02025-08-20T03:14:21ZengMDPI AGBiomolecules2218-273X2025-03-0115450410.3390/biom15040504Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice ChangesCarolina Alves Costa Silva0Andrew A. Almonte1Laurence Zitvogel2Gustave Roussy Cancer Campus (GRCC), Clinicobiome, 94805 Villejuif, FranceGustave Roussy Cancer Campus (GRCC), Clinicobiome, 94805 Villejuif, FranceGustave Roussy Cancer Campus (GRCC), Clinicobiome, 94805 Villejuif, FranceGrowing evidence suggests that cancer should not be viewed solely as a genetic disease but also as the result of functional defects in the metaorganism, including disturbances in the gut microbiota (i.e., gut dysbiosis). The human microbiota plays a critical role in regulating epithelial barrier function in the gut, airways, and skin, along with host metabolism and systemic immune responses against microbes and cancer. Collaborative international networks, such as ONCOBIOME, are essential in advancing research equity and building microbiome resources to identify and validate microbiota-related biomarkers and therapies. In this review, we explore the intricate relationship between the microbiome, metabolism, and cancer immunity, and we propose microbiota-based strategies to improve outcomes for individuals at risk of developing cancer or living with the disease.https://www.mdpi.com/2218-273X/15/4/504cancergutimmunotherapyimmuno-oncologymicrobiotamicrobiome |
| spellingShingle | Carolina Alves Costa Silva Andrew A. Almonte Laurence Zitvogel Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes Biomolecules cancer gut immunotherapy immuno-oncology microbiota microbiome |
| title | Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes |
| title_full | Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes |
| title_fullStr | Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes |
| title_full_unstemmed | Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes |
| title_short | Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes |
| title_sort | oncobiomics leveraging microbiome translational research in immuno oncology for clinical practice changes |
| topic | cancer gut immunotherapy immuno-oncology microbiota microbiome |
| url | https://www.mdpi.com/2218-273X/15/4/504 |
| work_keys_str_mv | AT carolinaalvescostasilva oncobiomicsleveragingmicrobiometranslationalresearchinimmunooncologyforclinicalpracticechanges AT andrewaalmonte oncobiomicsleveragingmicrobiometranslationalresearchinimmunooncologyforclinicalpracticechanges AT laurencezitvogel oncobiomicsleveragingmicrobiometranslationalresearchinimmunooncologyforclinicalpracticechanges |