Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021
Objectives: This study assesses the global, regional, and national burden of hepatitis B virus (HBV) and hepatitis C virus (HCV) related to injecting drug use (IDU) from 1990 to 2021. Methods: Data from the Global Burden of Disease Study 2021 were analyzed to quantify deaths, age-standardized mortal...
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Elsevier
2025-01-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224003643 |
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| author | Liang Huang Xiaoyu Chen Zhaojun Wang |
| author_facet | Liang Huang Xiaoyu Chen Zhaojun Wang |
| author_sort | Liang Huang |
| collection | DOAJ |
| description | Objectives: This study assesses the global, regional, and national burden of hepatitis B virus (HBV) and hepatitis C virus (HCV) related to injecting drug use (IDU) from 1990 to 2021. Methods: Data from the Global Burden of Disease Study 2021 were analyzed to quantify deaths, age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and age-standardized DALYs rates (ASDR) due to HBV and HCV from IDU across 204 countries. Trends were evaluated using estimated annual percentage change. Analyzing the association between ASDR and SDI using a loess regression model. Results: From 1990 to 2021, the global burden of deaths and DALYs due to HBV and HCV attributed to IDU showed an increasing trend, especially among males, whose mortality rates were significantly higher than females. In 2021, global deaths due to HBV from IDU were 13,050.8, with an ASMR of 0.15 per 100,000 and an ASDR of 5.3, both showing an increasing trend with estimated annual percentage changes (EAPCs) of 1.09 and 0.96, respectively. HCV deaths reached 231,764.4, with an ASMR of 2.68 (EAPC: 0.38) and a relatively stable ASDR trend (EAPC: 0.01). Although raw death rates for HCV have increased, the ASMR and ASDR have remained stable or slightly declined, highlighting different trends across sexes and regions. India had the highest national deaths, while the highest ASDRs were in the Republic of Moldova (HBV) and Mongolia (HCV). South Asia recorded the highest regional deaths for both HBV and HCV. Positive correlations between ASDRs for HBV and HCV with SDI were observed. Conclusion: The burden of HBV and HCV due to IDU has increased from 1990 to 2021, especially among males, with significant regional and national disparities. Targeted drug prohibition interventions and policies are needed. |
| format | Article |
| id | doaj-art-9f3a1bf75f3a400990cf14ee6d1be1f0 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | International Journal of Infectious Diseases |
| spelling | doaj-art-9f3a1bf75f3a400990cf14ee6d1be1f02025-08-20T02:48:58ZengElsevierInternational Journal of Infectious Diseases1201-97122025-01-0115010729310.1016/j.ijid.2024.107293Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021Liang Huang0Xiaoyu Chen1Zhaojun Wang2Department of Gastroenterology, Dongguan Kanghua Hospital, Dongguan, Guangdong, China; Corresponding author: Liang Huang, Department of Gastroenterology, Dongguan Kanghua Hospital, 1000 Dongguan Avenue, Dongguan 523123, Guangdong, China.Department of Pediatric Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei, ChinaDepartment of Thoracic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, ChinaObjectives: This study assesses the global, regional, and national burden of hepatitis B virus (HBV) and hepatitis C virus (HCV) related to injecting drug use (IDU) from 1990 to 2021. Methods: Data from the Global Burden of Disease Study 2021 were analyzed to quantify deaths, age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and age-standardized DALYs rates (ASDR) due to HBV and HCV from IDU across 204 countries. Trends were evaluated using estimated annual percentage change. Analyzing the association between ASDR and SDI using a loess regression model. Results: From 1990 to 2021, the global burden of deaths and DALYs due to HBV and HCV attributed to IDU showed an increasing trend, especially among males, whose mortality rates were significantly higher than females. In 2021, global deaths due to HBV from IDU were 13,050.8, with an ASMR of 0.15 per 100,000 and an ASDR of 5.3, both showing an increasing trend with estimated annual percentage changes (EAPCs) of 1.09 and 0.96, respectively. HCV deaths reached 231,764.4, with an ASMR of 2.68 (EAPC: 0.38) and a relatively stable ASDR trend (EAPC: 0.01). Although raw death rates for HCV have increased, the ASMR and ASDR have remained stable or slightly declined, highlighting different trends across sexes and regions. India had the highest national deaths, while the highest ASDRs were in the Republic of Moldova (HBV) and Mongolia (HCV). South Asia recorded the highest regional deaths for both HBV and HCV. Positive correlations between ASDRs for HBV and HCV with SDI were observed. Conclusion: The burden of HBV and HCV due to IDU has increased from 1990 to 2021, especially among males, with significant regional and national disparities. Targeted drug prohibition interventions and policies are needed.http://www.sciencedirect.com/science/article/pii/S1201971224003643Injecting drug useHepatitis BHepatitis CGlobal Burden of DiseaseAge-standardized rates |
| spellingShingle | Liang Huang Xiaoyu Chen Zhaojun Wang Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021 International Journal of Infectious Diseases Injecting drug use Hepatitis B Hepatitis C Global Burden of Disease Age-standardized rates |
| title | Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021 |
| title_full | Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021 |
| title_fullStr | Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021 |
| title_full_unstemmed | Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021 |
| title_short | Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021 |
| title_sort | total burden of hepatitis b and c attributed to injecting drug use in 204 countries and territories from 1990 to 2021 analyses based on the global burden of disease study 2021 |
| topic | Injecting drug use Hepatitis B Hepatitis C Global Burden of Disease Age-standardized rates |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224003643 |
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