Histological Dedifferentiation in Recurrent Adamantinoma of the Tibia: A Case Report
Introduction: Adamantinoma is a primary low-grade malignant bone tumor. It is most common in tibia with slight predilection in males. Dedifferentiated adamantinoma is an aggressive variant with worse prognosis. Case Report: Patient is a 70-year-old female who presented with leg pain. Imaging showed...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Indian Orthopaedic Research Group
2025-08-01
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| Series: | Journal of Orthopaedic Case Reports |
| Subjects: | |
| Online Access: | https://jocr.co.in/wp/2025/08/01/histological-dedifferentiation-in-recurrent-adamantinoma-of-the-tibia-a-case-reportpavithra-ethirajan1-archana-lakshmanan1/ |
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| Summary: | Introduction:
Adamantinoma is a primary low-grade malignant bone tumor. It is most common in tibia with slight predilection in males. Dedifferentiated adamantinoma is an aggressive variant with worse prognosis.
Case Report:
Patient is a 70-year-old female who presented with leg pain. Imaging showed a lytic lesion in the metaphyseo diaphyseal region. Curettings were done and were reported as adamantinoma. Two years later, the patient presented with a recurrent lesion at the same site. Histopathology showed a neoplasm with focal classical adamantinoma and many areas with aggressive morphology including sarcomatoid differentiation. The neoplastic cells in high-grade areas were positive for vimentin with variable loss of cytokeratin. Proliferative index as determined by Ki67 was 20–25% in these areas. With these given immuno-morphological findings, a diagnosis of dedifferentiated adamantinoma was rendered.
Conclusion:
Dedifferentiated adamantinoma is an unusual and aggressive variant of adamantinoma. This case highlights the awareness of such a rare entity, thereby preventing misdiagnosis and improper treatment. |
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| ISSN: | 2250-0685 2321-3817 |