MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level

MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level

IntroductionDrug-induced liver injury (DILI) has been investigated at the patient level. Analysis of gene perturbation at the cellular level can help better characterize biological mechanisms of hepatotoxicity. Despite accumulating drug-induced transcriptome data such as LINCS, analyzing such transc...

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Bibliographic Details
Main Authors:	Inyoung Sung, Sangseon Lee, Dongmin Bang, Jungseob Yi, Sunho Lee, Sun Kim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	drug-induced liver injury one-class boundary kernel distance transcriptomic signature degree of toxicity liver toxicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1398370/full
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