Galectin-3 Is a Potential Mediator for Atherosclerosis
Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke. Numerous studies have implicated inflammation as a key player in the initiation and progression of ather...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5284728 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566086887800832 |
|---|---|
| author | Ziyu Gao Zhongni Liu Rui Wang Yinghong Zheng Hong Li Liming Yang |
| author_facet | Ziyu Gao Zhongni Liu Rui Wang Yinghong Zheng Hong Li Liming Yang |
| author_sort | Ziyu Gao |
| collection | DOAJ |
| description | Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke. Numerous studies have implicated inflammation as a key player in the initiation and progression of atherosclerosis. Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. This review focuses on the role of Gal-3 in atherosclerosis and the mechanism involved and several classical Gal-3 agonists and antagonists in the current studies. |
| format | Article |
| id | doaj-art-9f24f0e2fbfa4e6fb0e1e127dcfa4513 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9f24f0e2fbfa4e6fb0e1e127dcfa45132025-02-03T01:05:16ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/52847285284728Galectin-3 Is a Potential Mediator for AtherosclerosisZiyu Gao0Zhongni Liu1Rui Wang2Yinghong Zheng3Hong Li4Liming Yang5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Beijing 100037, ChinaDepartment of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin 150081, ChinaYangpu Hospital, Tongji University, Shanghai 200090, ChinaDepartment of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin 150081, ChinaDepartment of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin 150081, ChinaState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Beijing 100037, ChinaAtherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke. Numerous studies have implicated inflammation as a key player in the initiation and progression of atherosclerosis. Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. This review focuses on the role of Gal-3 in atherosclerosis and the mechanism involved and several classical Gal-3 agonists and antagonists in the current studies.http://dx.doi.org/10.1155/2020/5284728 |
| spellingShingle | Ziyu Gao Zhongni Liu Rui Wang Yinghong Zheng Hong Li Liming Yang Galectin-3 Is a Potential Mediator for Atherosclerosis Journal of Immunology Research |
| title | Galectin-3 Is a Potential Mediator for Atherosclerosis |
| title_full | Galectin-3 Is a Potential Mediator for Atherosclerosis |
| title_fullStr | Galectin-3 Is a Potential Mediator for Atherosclerosis |
| title_full_unstemmed | Galectin-3 Is a Potential Mediator for Atherosclerosis |
| title_short | Galectin-3 Is a Potential Mediator for Atherosclerosis |
| title_sort | galectin 3 is a potential mediator for atherosclerosis |
| url | http://dx.doi.org/10.1155/2020/5284728 |
| work_keys_str_mv | AT ziyugao galectin3isapotentialmediatorforatherosclerosis AT zhongniliu galectin3isapotentialmediatorforatherosclerosis AT ruiwang galectin3isapotentialmediatorforatherosclerosis AT yinghongzheng galectin3isapotentialmediatorforatherosclerosis AT hongli galectin3isapotentialmediatorforatherosclerosis AT limingyang galectin3isapotentialmediatorforatherosclerosis |