Inhibitory effects of Spirulina in zymosan-induced arthritis in mice
The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase w...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350220131917 |
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| _version_ | 1832548135719665664 |
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| author | Diadelis Remirez Ricardo González Nelson Merino Sandra Rodriguez Odelsa Ancheta |
| author_facet | Diadelis Remirez Ricardo González Nelson Merino Sandra Rodriguez Odelsa Ancheta |
| author_sort | Diadelis Remirez |
| collection | DOAJ |
| description | The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported anti-inflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis. |
| format | Article |
| id | doaj-art-9f21d13401ac4220a0d0f1cc18e9d6dc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9f21d13401ac4220a0d0f1cc18e9d6dc2025-02-03T06:42:06ZengWileyMediators of Inflammation0962-93511466-18612002-01-01112757910.1080/09629350220131917Inhibitory effects of Spirulina in zymosan-induced arthritis in miceDiadelis Remirez0Ricardo González1Nelson Merino2Sandra Rodriguez3Odelsa Ancheta4Ozone International Center, Postbox 6412, Havana, CubaOzone International Center, Postbox 6412, Havana, CubaOzone International Center, Postbox 6412, Havana, CubaOzone International Center, Postbox 6412, Havana, CubaOzone International Center, Postbox 6412, Havana, CubaThe anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported anti-inflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis.http://dx.doi.org/10.1080/09629350220131917 |
| spellingShingle | Diadelis Remirez Ricardo González Nelson Merino Sandra Rodriguez Odelsa Ancheta Inhibitory effects of Spirulina in zymosan-induced arthritis in mice Mediators of Inflammation |
| title | Inhibitory effects of Spirulina in zymosan-induced arthritis in mice |
| title_full | Inhibitory effects of Spirulina in zymosan-induced arthritis in mice |
| title_fullStr | Inhibitory effects of Spirulina in zymosan-induced arthritis in mice |
| title_full_unstemmed | Inhibitory effects of Spirulina in zymosan-induced arthritis in mice |
| title_short | Inhibitory effects of Spirulina in zymosan-induced arthritis in mice |
| title_sort | inhibitory effects of spirulina in zymosan induced arthritis in mice |
| url | http://dx.doi.org/10.1080/09629350220131917 |
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