Metabolomic profiles of preterm small-for-gestational age infants
We aimed to characterize the metabolomic profiles in preterm small-for-gestational age (SGA) infants using cord blood. We conducted a gestational age (GA)-matched case-control study that included 30 preterm infants who were categorized into two groups: SGA infants, with a birth weight (BW) < 10th...
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Elsevier
2025-01-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957224000780 |
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| author | Koh Okuda Nobuhiko Nagano Kimitaka Nakazaki Kengo Matsuda Wataru Tokunaga Kazumasa Fuwa Ryoji Aoki Aya Okahashi Ichiro Morioka |
| author_facet | Koh Okuda Nobuhiko Nagano Kimitaka Nakazaki Kengo Matsuda Wataru Tokunaga Kazumasa Fuwa Ryoji Aoki Aya Okahashi Ichiro Morioka |
| author_sort | Koh Okuda |
| collection | DOAJ |
| description | We aimed to characterize the metabolomic profiles in preterm small-for-gestational age (SGA) infants using cord blood. We conducted a gestational age (GA)-matched case-control study that included 30 preterm infants who were categorized into two groups: SGA infants, with a birth weight (BW) < 10th percentile for GA (n = 15) and non-SGA infants, with BW ≥ 10th percentile for GA (n = 15). SGA infants with chromosomal or genetic abnormalities were excluded. At birth, the umbilicus was double-clamped, and the cord blood was sampled from the umbilical vein. Metabolomic analyses were performed using capillary electrophoresis time-of-flight mass spectrometry. The median GA at birth was not significantly different between the two groups [SGA, 32 (26–36) weeks; non-SGA, 32 (25–35) weeks; p = 0.661)]. Of the 255 metabolites analyzed, 19 (7.5%) showed significant differences between SGA and non-SGA infants. There were significant reductions in the carnosine, hypotaurine, and S-methylcysteine levels in SGA infants as compared to non-SGA infants (p < 0.05). Carnosine was correlated with gestational age, BMI before pregnancy, body weight gain during pregnancy (p = 0.002, p = 0.023, and p = 0.020, respectively). In conclusion, preterm SGA infants have low levels of cord blood antioxidative- and antiglycation-related metabolites, making them vulnerable to oxidative stress. |
| format | Article |
| id | doaj-art-9f1f2789e359437dbbf310e7a44a4cb2 |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-9f1f2789e359437dbbf310e7a44a4cb22025-01-25T04:11:04ZengElsevierPediatrics and Neonatology1875-95722025-01-016615054Metabolomic profiles of preterm small-for-gestational age infantsKoh Okuda0Nobuhiko Nagano1Kimitaka Nakazaki2Kengo Matsuda3Wataru Tokunaga4Kazumasa Fuwa5Ryoji Aoki6Aya Okahashi7Ichiro Morioka8Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanCorresponding author. Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi, Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanWe aimed to characterize the metabolomic profiles in preterm small-for-gestational age (SGA) infants using cord blood. We conducted a gestational age (GA)-matched case-control study that included 30 preterm infants who were categorized into two groups: SGA infants, with a birth weight (BW) < 10th percentile for GA (n = 15) and non-SGA infants, with BW ≥ 10th percentile for GA (n = 15). SGA infants with chromosomal or genetic abnormalities were excluded. At birth, the umbilicus was double-clamped, and the cord blood was sampled from the umbilical vein. Metabolomic analyses were performed using capillary electrophoresis time-of-flight mass spectrometry. The median GA at birth was not significantly different between the two groups [SGA, 32 (26–36) weeks; non-SGA, 32 (25–35) weeks; p = 0.661)]. Of the 255 metabolites analyzed, 19 (7.5%) showed significant differences between SGA and non-SGA infants. There were significant reductions in the carnosine, hypotaurine, and S-methylcysteine levels in SGA infants as compared to non-SGA infants (p < 0.05). Carnosine was correlated with gestational age, BMI before pregnancy, body weight gain during pregnancy (p = 0.002, p = 0.023, and p = 0.020, respectively). In conclusion, preterm SGA infants have low levels of cord blood antioxidative- and antiglycation-related metabolites, making them vulnerable to oxidative stress.http://www.sciencedirect.com/science/article/pii/S1875957224000780CarnosineGlycationHypotaurineOxidative stressS-metylcysteine |
| spellingShingle | Koh Okuda Nobuhiko Nagano Kimitaka Nakazaki Kengo Matsuda Wataru Tokunaga Kazumasa Fuwa Ryoji Aoki Aya Okahashi Ichiro Morioka Metabolomic profiles of preterm small-for-gestational age infants Pediatrics and Neonatology Carnosine Glycation Hypotaurine Oxidative stress S-metylcysteine |
| title | Metabolomic profiles of preterm small-for-gestational age infants |
| title_full | Metabolomic profiles of preterm small-for-gestational age infants |
| title_fullStr | Metabolomic profiles of preterm small-for-gestational age infants |
| title_full_unstemmed | Metabolomic profiles of preterm small-for-gestational age infants |
| title_short | Metabolomic profiles of preterm small-for-gestational age infants |
| title_sort | metabolomic profiles of preterm small for gestational age infants |
| topic | Carnosine Glycation Hypotaurine Oxidative stress S-metylcysteine |
| url | http://www.sciencedirect.com/science/article/pii/S1875957224000780 |
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