Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4

Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4

Abstract Background Cancer-associated fibroblasts (CAFs) are key components of tumor microenvironment and have been identified to be involved in modulating drug resistance in cancers by secreting molecules. Pancreatic cancer (PC) is a leading cause of cancer mortality with high aggressiveness. Gemci...

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Bibliographic Details
Main Authors: Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
Gemcitabine
Chemoresistance
Stemness
CAFs
COL17A1
ACTN4
Online Access:https://doi.org/10.1007/s12672-025-01825-8
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