Amino acid metabolism in glioblastoma pathogenesis, immune evasion, and treatment resistance

Amino acid metabolism in glioblastoma pathogenesis, immune evasion, and treatment resistance

Abstract Glioblastoma (GBM) ranks among the most lethal primary tumors of the central nervous system. This is partly due to its complex intracellular metabolism and interactions with the surrounding tumor microenvironment (TME). Compelling evidence represents that altered amino acids (AAs) metabolis...

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Main Authors: Shriyansh Srivastava, Robab Anbiaee, Mohammad Houshyari, Laxmi, Sathvik Belagodu Sridhar, Sumel Ashique, Sadique Hussain, Sachin Kumar, Tahreen Taj, Zeinab Akbarnejad, Farzad Taghizadeh-Hesary
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Amino acids
Tumor microenvironment
Metabolic pathways
Immunosuppression
Online Access:https://doi.org/10.1186/s12935-025-03721-1
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