The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression
The function of natural killer (NK) cells, defending against virus infection and tumour progression, is regulated by multiple activating and inhibiting receptors expressed on NK cells, among which sialic acid-bind immunoglobulin-like lectins (Siglecs) act as a vital inhibitory group. Previous studie...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6243819 |
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| author | Yayun Zheng Xue Ma Dongmei Su Yue Zhang Lin Yu Fangfei Jiang Xue Zhou Ying Feng Fang Ma |
| author_facet | Yayun Zheng Xue Ma Dongmei Su Yue Zhang Lin Yu Fangfei Jiang Xue Zhou Ying Feng Fang Ma |
| author_sort | Yayun Zheng |
| collection | DOAJ |
| description | The function of natural killer (NK) cells, defending against virus infection and tumour progression, is regulated by multiple activating and inhibiting receptors expressed on NK cells, among which sialic acid-bind immunoglobulin-like lectins (Siglecs) act as a vital inhibitory group. Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands. Siglec7 and Siglec9 are very similar in distribution, gene encoding, protein sequences, ligand affinity, and functions in regulating the immune system against virus and cancers, but differences still exist between them. In this review, we aim to discuss the similarities and differences between Siglec7 and Siglec9 and analyze their functions in virus infection and tumour progression in order to develop better anti-viral and anti-tumor immunotherapy in the future. |
| format | Article |
| id | doaj-art-9f18c8b3327f4ebf9d7ed21cd5051c20 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9f18c8b3327f4ebf9d7ed21cd5051c202025-02-03T01:25:49ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/62438196243819The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour ProgressionYayun Zheng0Xue Ma1Dongmei Su2Yue Zhang3Lin Yu4Fangfei Jiang5Xue Zhou6Ying Feng7Fang Ma8Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Pediatric Urology, West China University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Histology, Embryology and Neurobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Histology, Embryology and Neurobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, ChinaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaThe function of natural killer (NK) cells, defending against virus infection and tumour progression, is regulated by multiple activating and inhibiting receptors expressed on NK cells, among which sialic acid-bind immunoglobulin-like lectins (Siglecs) act as a vital inhibitory group. Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands. Siglec7 and Siglec9 are very similar in distribution, gene encoding, protein sequences, ligand affinity, and functions in regulating the immune system against virus and cancers, but differences still exist between them. In this review, we aim to discuss the similarities and differences between Siglec7 and Siglec9 and analyze their functions in virus infection and tumour progression in order to develop better anti-viral and anti-tumor immunotherapy in the future.http://dx.doi.org/10.1155/2020/6243819 |
| spellingShingle | Yayun Zheng Xue Ma Dongmei Su Yue Zhang Lin Yu Fangfei Jiang Xue Zhou Ying Feng Fang Ma The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression Journal of Immunology Research |
| title | The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression |
| title_full | The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression |
| title_fullStr | The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression |
| title_full_unstemmed | The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression |
| title_short | The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression |
| title_sort | roles of siglec7 and siglec9 on natural killer cells in virus infection and tumour progression |
| url | http://dx.doi.org/10.1155/2020/6243819 |
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