Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation
The first treatment for multiple sclerosis exacerbation is usually short-term intravenous methylprednisolone (IVMP), with or without a regimen of oral prednisone taper (OPT). This study aims to evaluate the effects of IVMP and OPT in comparison with IVMP alone in raising the risk of urinary tract in...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/6616763 |
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| author | Aliyeh Bazi Seyed Mohammad Baghbanian Monireh Ghazaeian Sahar Fallah Narjes Hendoiee |
| author_facet | Aliyeh Bazi Seyed Mohammad Baghbanian Monireh Ghazaeian Sahar Fallah Narjes Hendoiee |
| author_sort | Aliyeh Bazi |
| collection | DOAJ |
| description | The first treatment for multiple sclerosis exacerbation is usually short-term intravenous methylprednisolone (IVMP), with or without a regimen of oral prednisone taper (OPT). This study aims to evaluate the effects of IVMP and OPT in comparison with IVMP alone in raising the risk of urinary tract infection (UTI) and posttreatment improvement of urinary tract symptoms in patients with relapsing-remitting multiple sclerosis. This double-blind randomized clinical trial was conducted on 56 people with multiple sclerosis relapse who had undergone methylprednisolone for 5 days. Patients were randomly split into two groups: oral prednisolone and placebo (tapering for 20 days). Demographic data, duration of multiple sclerosis, urinary tract symptoms, the Expanded Disability Status Scale (EDSS) score, and urine data were analyzed. The incidence of UTI in the intervention and control groups did not differ significantly (p=560). However, the improvement of urinary tract symptoms in the intervention group was significantly more favorable than in the control group (p≤0.001). Furthermore, administering OPT after IVMP did not increase the risk of UTI occurrence in patients with multiple sclerosis exacerbation. The urine analysis results did not show any differences at baseline and after the corticosteroid tapering regimen. Due to the risk of infection by corticosteroids, it is no longer necessary to do further urinary screening in this group of patients. |
| format | Article |
| id | doaj-art-9efbf09539864571acc0feecad620219 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-9efbf09539864571acc0feecad6202192025-02-03T06:46:44ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932021-01-01202110.1155/2021/66167636616763Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis ExacerbationAliyeh Bazi0Seyed Mohammad Baghbanian1Monireh Ghazaeian2Sahar Fallah3Narjes Hendoiee4Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IranDepartment of Neurology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IranDepartment of Biostatistic, Ibne Sina Medical and Educational Center, Mazandaran University of Medical Sciences, Sari, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IranThe first treatment for multiple sclerosis exacerbation is usually short-term intravenous methylprednisolone (IVMP), with or without a regimen of oral prednisone taper (OPT). This study aims to evaluate the effects of IVMP and OPT in comparison with IVMP alone in raising the risk of urinary tract infection (UTI) and posttreatment improvement of urinary tract symptoms in patients with relapsing-remitting multiple sclerosis. This double-blind randomized clinical trial was conducted on 56 people with multiple sclerosis relapse who had undergone methylprednisolone for 5 days. Patients were randomly split into two groups: oral prednisolone and placebo (tapering for 20 days). Demographic data, duration of multiple sclerosis, urinary tract symptoms, the Expanded Disability Status Scale (EDSS) score, and urine data were analyzed. The incidence of UTI in the intervention and control groups did not differ significantly (p=560). However, the improvement of urinary tract symptoms in the intervention group was significantly more favorable than in the control group (p≤0.001). Furthermore, administering OPT after IVMP did not increase the risk of UTI occurrence in patients with multiple sclerosis exacerbation. The urine analysis results did not show any differences at baseline and after the corticosteroid tapering regimen. Due to the risk of infection by corticosteroids, it is no longer necessary to do further urinary screening in this group of patients.http://dx.doi.org/10.1155/2021/6616763 |
| spellingShingle | Aliyeh Bazi Seyed Mohammad Baghbanian Monireh Ghazaeian Sahar Fallah Narjes Hendoiee Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation |
| title_full | Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation |
| title_fullStr | Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation |
| title_full_unstemmed | Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation |
| title_short | Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation |
| title_sort | evaluation of urinary tract infection following corticosteroid therapy in patients with multiple sclerosis exacerbation |
| url | http://dx.doi.org/10.1155/2021/6616763 |
| work_keys_str_mv | AT aliyehbazi evaluationofurinarytractinfectionfollowingcorticosteroidtherapyinpatientswithmultiplesclerosisexacerbation AT seyedmohammadbaghbanian evaluationofurinarytractinfectionfollowingcorticosteroidtherapyinpatientswithmultiplesclerosisexacerbation AT monirehghazaeian evaluationofurinarytractinfectionfollowingcorticosteroidtherapyinpatientswithmultiplesclerosisexacerbation AT saharfallah evaluationofurinarytractinfectionfollowingcorticosteroidtherapyinpatientswithmultiplesclerosisexacerbation AT narjeshendoiee evaluationofurinarytractinfectionfollowingcorticosteroidtherapyinpatientswithmultiplesclerosisexacerbation |