A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019
We aimed to investigate changes in pulmonary function and computed tomography (CT) findings in patients with coronavirus disease 2019 (COVID-19) during the recovery period. COVID-19 patients underwent symptom assessment, pulmonary function tests, and high-resolution chest CT 6 months after discharge...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/6692409 |
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| author | Qian Wu Lingshan Zhong Hongwei Li Jing Guo Yajie Li Xinwei Hou Fangfei Yang Yi Xie Li Li Zhiheng Xing |
| author_facet | Qian Wu Lingshan Zhong Hongwei Li Jing Guo Yajie Li Xinwei Hou Fangfei Yang Yi Xie Li Li Zhiheng Xing |
| author_sort | Qian Wu |
| collection | DOAJ |
| description | We aimed to investigate changes in pulmonary function and computed tomography (CT) findings in patients with coronavirus disease 2019 (COVID-19) during the recovery period. COVID-19 patients underwent symptom assessment, pulmonary function tests, and high-resolution chest CT 6 months after discharge from the hospital. Of the 54 patients enrolled, 31 and 23 were in the moderate and severe group, respectively. The main symptoms 6 months after discharge were fatigue and exertional dyspnea, experienced by 24.1% and 18.5% of patients, respectively, followed by smell and taste dysfunction (9.3%) and cough (5.6%). One patient dropped out of the pulmonary function tests. Of the remaining 54 patients, 41.5% had pulmonary dysfunction. Specifically, 7.5% presented with restrictive ventilatory dysfunction (forced vital capacity <80% of the predicted value), 18.9% presented with small airway dysfunction, and 32.1% presented with pulmonary diffusion impairment (diffusing capacity for carbon monoxide <80% of the predicted value). Of the 54 patients enrolled, six patients dropped out of the chest CT tests. Eleven of the remaining 48 patients presented with abnormal lung CT findings 6 months after discharge. Patients with residual lung lesions were more common in the severe group (52.6%) than in the moderate group (3.4%); a higher proportion of patients had involvement of both lungs (42.1% vs. 3.4%) in the severe group. The residual lung lesions were mainly ground-glass opacities (20.8%) and linear opacities (14.6%). Semiquantitative visual scoring of the CT findings revealed significantly higher scores in the left, right, and both lungs in the severe group than in the moderate group. COVID-19 patients 6 months after discharge mostly presented with fatigue and exertional dyspnea, and their pulmonary dysfunction was mostly characterized by pulmonary diffusion impairment. As revealed by chest CT, the severe group had a higher prevalence of residual lesions than the moderate group, and the residual lesions mostly manifested as ground-glass opacities and linear opacities. |
| format | Article |
| id | doaj-art-9efb7c19adca45279f2c22d921bdfae6 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-9efb7c19adca45279f2c22d921bdfae62025-02-03T01:00:17ZengWileyCanadian Respiratory Journal1198-22411916-72452021-01-01202110.1155/2021/66924096692409A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019Qian Wu0Lingshan Zhong1Hongwei Li2Jing Guo3Yajie Li4Xinwei Hou5Fangfei Yang6Yi Xie7Li Li8Zhiheng Xing9Department of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaTianjin Institute of Respiratory Diseases, Tianjin 300350, ChinaDepartment of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaDepartment of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaDepartment of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaDepartment of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaDepartment of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaTianjin Institute of Respiratory Diseases, Tianjin 300350, ChinaDepartment of Respiratory Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, ChinaTianjin Institute of Respiratory Diseases, Tianjin 300350, ChinaWe aimed to investigate changes in pulmonary function and computed tomography (CT) findings in patients with coronavirus disease 2019 (COVID-19) during the recovery period. COVID-19 patients underwent symptom assessment, pulmonary function tests, and high-resolution chest CT 6 months after discharge from the hospital. Of the 54 patients enrolled, 31 and 23 were in the moderate and severe group, respectively. The main symptoms 6 months after discharge were fatigue and exertional dyspnea, experienced by 24.1% and 18.5% of patients, respectively, followed by smell and taste dysfunction (9.3%) and cough (5.6%). One patient dropped out of the pulmonary function tests. Of the remaining 54 patients, 41.5% had pulmonary dysfunction. Specifically, 7.5% presented with restrictive ventilatory dysfunction (forced vital capacity <80% of the predicted value), 18.9% presented with small airway dysfunction, and 32.1% presented with pulmonary diffusion impairment (diffusing capacity for carbon monoxide <80% of the predicted value). Of the 54 patients enrolled, six patients dropped out of the chest CT tests. Eleven of the remaining 48 patients presented with abnormal lung CT findings 6 months after discharge. Patients with residual lung lesions were more common in the severe group (52.6%) than in the moderate group (3.4%); a higher proportion of patients had involvement of both lungs (42.1% vs. 3.4%) in the severe group. The residual lung lesions were mainly ground-glass opacities (20.8%) and linear opacities (14.6%). Semiquantitative visual scoring of the CT findings revealed significantly higher scores in the left, right, and both lungs in the severe group than in the moderate group. COVID-19 patients 6 months after discharge mostly presented with fatigue and exertional dyspnea, and their pulmonary dysfunction was mostly characterized by pulmonary diffusion impairment. As revealed by chest CT, the severe group had a higher prevalence of residual lesions than the moderate group, and the residual lesions mostly manifested as ground-glass opacities and linear opacities.http://dx.doi.org/10.1155/2021/6692409 |
| spellingShingle | Qian Wu Lingshan Zhong Hongwei Li Jing Guo Yajie Li Xinwei Hou Fangfei Yang Yi Xie Li Li Zhiheng Xing A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 Canadian Respiratory Journal |
| title | A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 |
| title_full | A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 |
| title_fullStr | A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 |
| title_full_unstemmed | A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 |
| title_short | A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 |
| title_sort | follow up study of lung function and chest computed tomography at 6 months after discharge in patients with coronavirus disease 2019 |
| url | http://dx.doi.org/10.1155/2021/6692409 |
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