Neglected adult PFAPA syndrome
Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome is rarely seen in adults. The diagnosis is challenging, and the majority of cases are misdiagnosed early. Here we present a case of a 69-year-old woman with PFAPA syndrome, initially misdiagnosed as pharyngitis o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325000524 |
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| author | Aiping Zhang Ruifeng Zhang Yiling Jiang Ling Shi Meihong Luo |
| author_facet | Aiping Zhang Ruifeng Zhang Yiling Jiang Ling Shi Meihong Luo |
| author_sort | Aiping Zhang |
| collection | DOAJ |
| description | Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome is rarely seen in adults. The diagnosis is challenging, and the majority of cases are misdiagnosed early. Here we present a case of a 69-year-old woman with PFAPA syndrome, initially misdiagnosed as pharyngitis or lymphadenitis and received multiple antibiotic therapy without any clinical benefit. This report emphasizes the importance of early identification of the disease. Patients with periodic fever accompanied by cervical lymphadenitis, clinicians should consider the possibility of PFAPA syndrome especially when antibiotic treatment is ineffective. The case showed that colchicine could significantly prolong the interval between fever, with the longest interval reaching 8 months, which significantly improved the patient's quality of life (QOL). |
| format | Article |
| id | doaj-art-9ef9d8d1c92043529ee44deaeacedb43 |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-9ef9d8d1c92043529ee44deaeacedb432025-01-31T05:11:13ZengElsevierRadiology Case Reports1930-04332025-04-0120421162122Neglected adult PFAPA syndromeAiping Zhang0Ruifeng Zhang1Yiling Jiang2Ling Shi3Meihong Luo4Department of Hematology, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, ChinaDepartment of Hematology, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, ChinaDepartment of Hematology, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, ChinaDepartment of Hematology, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, ChinaCorresponding author.; Department of Hematology, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, ChinaPeriodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome is rarely seen in adults. The diagnosis is challenging, and the majority of cases are misdiagnosed early. Here we present a case of a 69-year-old woman with PFAPA syndrome, initially misdiagnosed as pharyngitis or lymphadenitis and received multiple antibiotic therapy without any clinical benefit. This report emphasizes the importance of early identification of the disease. Patients with periodic fever accompanied by cervical lymphadenitis, clinicians should consider the possibility of PFAPA syndrome especially when antibiotic treatment is ineffective. The case showed that colchicine could significantly prolong the interval between fever, with the longest interval reaching 8 months, which significantly improved the patient's quality of life (QOL).http://www.sciencedirect.com/science/article/pii/S1930043325000524Periodic feverAdultPFAPA syndromeColchicine |
| spellingShingle | Aiping Zhang Ruifeng Zhang Yiling Jiang Ling Shi Meihong Luo Neglected adult PFAPA syndrome Radiology Case Reports Periodic fever Adult PFAPA syndrome Colchicine |
| title | Neglected adult PFAPA syndrome |
| title_full | Neglected adult PFAPA syndrome |
| title_fullStr | Neglected adult PFAPA syndrome |
| title_full_unstemmed | Neglected adult PFAPA syndrome |
| title_short | Neglected adult PFAPA syndrome |
| title_sort | neglected adult pfapa syndrome |
| topic | Periodic fever Adult PFAPA syndrome Colchicine |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325000524 |
| work_keys_str_mv | AT aipingzhang neglectedadultpfapasyndrome AT ruifengzhang neglectedadultpfapasyndrome AT yilingjiang neglectedadultpfapasyndrome AT lingshi neglectedadultpfapasyndrome AT meihongluo neglectedadultpfapasyndrome |