Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes
Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexe...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2017/4276919 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567601892425728 |
|---|---|
| author | Yanmin Huang Erbin Kong Junyan Zhan Shuang Chen Chunfang Gan Zhiping Liu Liping Pang Jianguo Cui |
| author_facet | Yanmin Huang Erbin Kong Junyan Zhan Shuang Chen Chunfang Gan Zhiping Liu Liping Pang Jianguo Cui |
| author_sort | Yanmin Huang |
| collection | DOAJ |
| description | Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexes were characterized by IR, NMR, and HRMS. The synthesized compounds were screened for their cytotoxicity against HeLa, Bel-7404, and 293T cell lines in vitro. The results show that all steroidal copper (II) complexes display obvious antiproliferative activity against the tested cancer cells. The IC50 values of complexes 5 and 12 against Bel-7404 (human liver carcinoma) are 5.0 and 7.0 μM. |
| format | Article |
| id | doaj-art-9eeff68f73d542d8b856fbd99fa4432f |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-9eeff68f73d542d8b856fbd99fa4432f2025-02-03T01:01:01ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2017-01-01201710.1155/2017/42769194276919Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) ComplexesYanmin Huang0Erbin Kong1Junyan Zhan2Shuang Chen3Chunfang Gan4Zhiping Liu5Liping Pang6Jianguo Cui7Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaKey Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, ChinaUsing estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexes were characterized by IR, NMR, and HRMS. The synthesized compounds were screened for their cytotoxicity against HeLa, Bel-7404, and 293T cell lines in vitro. The results show that all steroidal copper (II) complexes display obvious antiproliferative activity against the tested cancer cells. The IC50 values of complexes 5 and 12 against Bel-7404 (human liver carcinoma) are 5.0 and 7.0 μM.http://dx.doi.org/10.1155/2017/4276919 |
| spellingShingle | Yanmin Huang Erbin Kong Junyan Zhan Shuang Chen Chunfang Gan Zhiping Liu Liping Pang Jianguo Cui Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes |
| title_full | Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes |
| title_fullStr | Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes |
| title_full_unstemmed | Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes |
| title_short | Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes |
| title_sort | synthesis and cytotoxic evaluation of steroidal copper cu ii complexes |
| url | http://dx.doi.org/10.1155/2017/4276919 |
| work_keys_str_mv | AT yanminhuang synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT erbinkong synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT junyanzhan synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT shuangchen synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT chunfanggan synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT zhipingliu synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT lipingpang synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes AT jianguocui synthesisandcytotoxicevaluationofsteroidalcoppercuiicomplexes |