Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy
Purpose. The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy. Methods and Materials. Diabetic breast cancer patients receiving concurrent metformin and radiation therapy were matched with nondiabet...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/659723 |
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| author | Adam Ferro Sharad Goyal Sinae Kim Hao Wu Neil K. Taunk Devora Schiff Aneesh Pirlamarla Bruce G. Haffty |
| author_facet | Adam Ferro Sharad Goyal Sinae Kim Hao Wu Neil K. Taunk Devora Schiff Aneesh Pirlamarla Bruce G. Haffty |
| author_sort | Adam Ferro |
| collection | DOAJ |
| description | Purpose. The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy. Methods and Materials. Diabetic breast cancer patients receiving concurrent metformin and radiation therapy were matched with nondiabetic patients and diabetic patients using an alternative diabetes medication. Primary endpoints included the presence of a treatment break and development of dry or moist desquamation. Results. There was a statistically significant increase in treatment breaks for diabetic patients receiving concurrent metformin when compared to the nondiabetic patients (P value = 0.02) and a trend toward significance when compared to diabetic patients receiving an alternate diabetes medication (P value = 0.08). Multiple logistic regression analysis demonstrated concurrent metformin use as being associated with a trend toward the predictive value of determining the incidence of developing desquamation in diabetic patients receiving radiation therapy compared to diabetic patients receiving an alternate diabetes medication (P value = 0.06). Conclusions. Diabetic patients treated with concurrent metformin and radiation therapy developed increased acute locoregional toxicity in comparison with diabetic patients receiving an alternate diabetes medication and nondiabetic patients. Further clinical investigation should be conducted to determine the therapeutic ratio of metformin in combination with radiation therapy. |
| format | Article |
| id | doaj-art-9ec9a5176ab845f8a0aa0822be3ae345 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-9ec9a5176ab845f8a0aa0822be3ae3452025-02-03T01:03:01ZengWileyInternational Journal of Breast Cancer2090-31702090-31892013-01-01201310.1155/2013/659723659723Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant RadiotherapyAdam Ferro0Sharad Goyal1Sinae Kim2Hao Wu3Neil K. Taunk4Devora Schiff5Aneesh Pirlamarla6Bruce G. Haffty7Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, New Jersey 08903, USADepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, New Jersey 08903, USADepartment of Biostatistics, Rutgers Cancer Institute of New Jersey and Rutgers School of Public Health, New Brunswick, New Jersey 08903, USADepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, New Jersey 08903, USADepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USADepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, New Jersey 08903, USADepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, New Jersey 08903, USADepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, New Jersey 08903, USAPurpose. The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy. Methods and Materials. Diabetic breast cancer patients receiving concurrent metformin and radiation therapy were matched with nondiabetic patients and diabetic patients using an alternative diabetes medication. Primary endpoints included the presence of a treatment break and development of dry or moist desquamation. Results. There was a statistically significant increase in treatment breaks for diabetic patients receiving concurrent metformin when compared to the nondiabetic patients (P value = 0.02) and a trend toward significance when compared to diabetic patients receiving an alternate diabetes medication (P value = 0.08). Multiple logistic regression analysis demonstrated concurrent metformin use as being associated with a trend toward the predictive value of determining the incidence of developing desquamation in diabetic patients receiving radiation therapy compared to diabetic patients receiving an alternate diabetes medication (P value = 0.06). Conclusions. Diabetic patients treated with concurrent metformin and radiation therapy developed increased acute locoregional toxicity in comparison with diabetic patients receiving an alternate diabetes medication and nondiabetic patients. Further clinical investigation should be conducted to determine the therapeutic ratio of metformin in combination with radiation therapy.http://dx.doi.org/10.1155/2013/659723 |
| spellingShingle | Adam Ferro Sharad Goyal Sinae Kim Hao Wu Neil K. Taunk Devora Schiff Aneesh Pirlamarla Bruce G. Haffty Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy International Journal of Breast Cancer |
| title | Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy |
| title_full | Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy |
| title_fullStr | Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy |
| title_full_unstemmed | Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy |
| title_short | Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy |
| title_sort | evaluation of diabetic patients with breast cancer treated with metformin during adjuvant radiotherapy |
| url | http://dx.doi.org/10.1155/2013/659723 |
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