Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development....
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.49 |
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| _version_ | 1832564492268994560 |
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| author | Shiv K. Sharma |
| author_facet | Shiv K. Sharma |
| author_sort | Shiv K. Sharma |
| collection | DOAJ |
| description | The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease. |
| format | Article |
| id | doaj-art-9ec3b12f866b437fb0c34bb00c5eecbb |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9ec3b12f866b437fb0c34bb00c5eecbb2025-02-03T01:10:57ZengWileyThe Scientific World Journal1537-744X2010-01-011045746110.1100/tsw.2010.49Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's DiseaseShiv K. Sharma0National Brain Research Centre, Manesar, Haryana-122050, IndiaThe hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease.http://dx.doi.org/10.1100/tsw.2010.49 |
| spellingShingle | Shiv K. Sharma Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease The Scientific World Journal |
| title | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_full | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_fullStr | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_full_unstemmed | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_short | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_sort | hepatocyte growth factor in synaptic plasticity and alzheimer s disease |
| url | http://dx.doi.org/10.1100/tsw.2010.49 |
| work_keys_str_mv | AT shivksharma hepatocytegrowthfactorinsynapticplasticityandalzheimersdisease |