Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies
Monkeypox (mpox) is a viral infection closely related to smallpox, manifesting as a milder febrile rash in affected individuals. Over the past two decades, the incidence of mpox has surged, possibly linked to a declining immunity against the smallpox vaccine worldwide. Recent outbreaks of mpox in mu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/1/1 |
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| author | Suresh Kumar Dhanyashri Guruparan Kalimuthu Karuppanan K. J. Senthil Kumar |
| author_facet | Suresh Kumar Dhanyashri Guruparan Kalimuthu Karuppanan K. J. Senthil Kumar |
| author_sort | Suresh Kumar |
| collection | DOAJ |
| description | Monkeypox (mpox) is a viral infection closely related to smallpox, manifesting as a milder febrile rash in affected individuals. Over the past two decades, the incidence of mpox has surged, possibly linked to a declining immunity against the smallpox vaccine worldwide. Recent outbreaks of mpox in multiple countries have sparked concerns regarding altered transmission patterns and the potential for a global menace. In this article, we present a multidimensional review encompassing the latest scientific discoveries, illuminating the intricate structure of the human mpox virus. Key findings include advancements in understanding the virus’s molecular mechanisms, which highlight its genetic adaptability and potential for zoonotic spillover. Diagnostic innovations, such as improved molecular assays, have enhanced detection accuracy, while novel therapeutic strategies, including antiviral drugs and vaccines, show promise in mitigating outbreaks. Our conclusions emphasize the importance of robust surveillance systems, vaccination programs, and rapid response strategies to curb mpox’s spread. Future recommendations include strengthening global collaboration for zoonotic disease surveillance, advancing the research on host–pathogen interactions, and developing next-generation therapeutics to address this emerging public health threat effectively. |
| format | Article |
| id | doaj-art-9ec0a4e673364ecbb46a2cd923fefe84 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-9ec0a4e673364ecbb46a2cd923fefe842025-01-24T13:44:32ZengMDPI AGPathogens2076-08172024-12-01141110.3390/pathogens14010001Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic StrategiesSuresh Kumar0Dhanyashri Guruparan1Kalimuthu Karuppanan2K. J. Senthil Kumar3Faculty of Health and Life Sciences, Management and Science University, Shah Alam 40100, MalaysiaFaculty of Health and Life Sciences, Management and Science University, Shah Alam 40100, MalaysiaDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, IndiaCenter for General Education, National Chung Hsing University, Taichung 402, TaiwanMonkeypox (mpox) is a viral infection closely related to smallpox, manifesting as a milder febrile rash in affected individuals. Over the past two decades, the incidence of mpox has surged, possibly linked to a declining immunity against the smallpox vaccine worldwide. Recent outbreaks of mpox in multiple countries have sparked concerns regarding altered transmission patterns and the potential for a global menace. In this article, we present a multidimensional review encompassing the latest scientific discoveries, illuminating the intricate structure of the human mpox virus. Key findings include advancements in understanding the virus’s molecular mechanisms, which highlight its genetic adaptability and potential for zoonotic spillover. Diagnostic innovations, such as improved molecular assays, have enhanced detection accuracy, while novel therapeutic strategies, including antiviral drugs and vaccines, show promise in mitigating outbreaks. Our conclusions emphasize the importance of robust surveillance systems, vaccination programs, and rapid response strategies to curb mpox’s spread. Future recommendations include strengthening global collaboration for zoonotic disease surveillance, advancing the research on host–pathogen interactions, and developing next-generation therapeutics to address this emerging public health threat effectively.https://www.mdpi.com/2076-0817/14/1/1orthopoxvirusmonkeypoxzoonotic diseasesvaccine |
| spellingShingle | Suresh Kumar Dhanyashri Guruparan Kalimuthu Karuppanan K. J. Senthil Kumar Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies Pathogens orthopoxvirus monkeypox zoonotic diseases vaccine |
| title | Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies |
| title_full | Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies |
| title_fullStr | Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies |
| title_full_unstemmed | Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies |
| title_short | Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies |
| title_sort | comprehensive insights into monkeypox mpox recent advances in epidemiology diagnostic approaches and therapeutic strategies |
| topic | orthopoxvirus monkeypox zoonotic diseases vaccine |
| url | https://www.mdpi.com/2076-0817/14/1/1 |
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