The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
Objective. The aim of our study was to explore the dependent condition of the relationship between uric acid and blood glucose in type 2 diabetes. Research Design and Methods. We measured the HbA1c, serum uric acid, creatinine, lipids profiles, and so forth of 605 newly diagnosed type 2 diabetes pat...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7184123 |
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| author | Yuliang Cui Hemei Bu Xianghua Ma Sha Zhao Xiaona Li Shan Lu |
| author_facet | Yuliang Cui Hemei Bu Xianghua Ma Sha Zhao Xiaona Li Shan Lu |
| author_sort | Yuliang Cui |
| collection | DOAJ |
| description | Objective. The aim of our study was to explore the dependent condition of the relationship between uric acid and blood glucose in type 2 diabetes. Research Design and Methods. We measured the HbA1c, serum uric acid, creatinine, lipids profiles, and so forth of 605 newly diagnosed type 2 diabetes patients, and oral glucose tolerance tests (OGTTs) were performed on each patient. The population was divided into high and low insulin groups. Multiple linear regression analyses were conducted to assess the relationship between uric acid and HbA1c. Results. Serum uric acid and HbA1c levels were low in newly diagnosed type 2 diabetes patients. However, we found no significant relationship between uric acid and HbA1c by regression analysis after adjusting total insulin. The concentration of uric acid was inversely correlated with HbA1c in the high insulin group, regardless of patient sex. However, no associations were found in low insulin group. Conclusions. The negative correlation between uric acid and HbA1c is conditional in newly diagnosed type 2 diabetes patients and is related to hyperinsulinemia. Therefore, uric acid is likely only useful as a biomarker of blood glucose in patients exhibiting hyperinsulinemia. |
| format | Article |
| id | doaj-art-9eae76a702ad475ca44dd2efd8aaef3b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9eae76a702ad475ca44dd2efd8aaef3b2025-02-03T01:29:55ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/71841237184123The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes MellitusYuliang Cui0Hemei Bu1Xianghua Ma2Sha Zhao3Xiaona Li4Shan Lu5Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaObjective. The aim of our study was to explore the dependent condition of the relationship between uric acid and blood glucose in type 2 diabetes. Research Design and Methods. We measured the HbA1c, serum uric acid, creatinine, lipids profiles, and so forth of 605 newly diagnosed type 2 diabetes patients, and oral glucose tolerance tests (OGTTs) were performed on each patient. The population was divided into high and low insulin groups. Multiple linear regression analyses were conducted to assess the relationship between uric acid and HbA1c. Results. Serum uric acid and HbA1c levels were low in newly diagnosed type 2 diabetes patients. However, we found no significant relationship between uric acid and HbA1c by regression analysis after adjusting total insulin. The concentration of uric acid was inversely correlated with HbA1c in the high insulin group, regardless of patient sex. However, no associations were found in low insulin group. Conclusions. The negative correlation between uric acid and HbA1c is conditional in newly diagnosed type 2 diabetes patients and is related to hyperinsulinemia. Therefore, uric acid is likely only useful as a biomarker of blood glucose in patients exhibiting hyperinsulinemia.http://dx.doi.org/10.1155/2016/7184123 |
| spellingShingle | Yuliang Cui Hemei Bu Xianghua Ma Sha Zhao Xiaona Li Shan Lu The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus |
| title_full | The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus |
| title_fullStr | The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus |
| title_short | The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus |
| title_sort | relation between serum uric acid and hba1c is dependent upon hyperinsulinemia in patients with newly diagnosed type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2016/7184123 |
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