Pharmacodynamic approaches to the use of mucoactive drugs
Cough is a reflex, protective and adaptive reaction of the body aimed at removing foreign sub-stances and/or pathologically altered tracheobronchial secretions from the respiratory tract. Cough is one of the most important components of pulmonary clearance, which is activated when natural mechanisms...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Open Systems Publication
2021-06-01
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| Series: | Лечащий Врач |
| Subjects: | |
| Online Access: | https://journal.lvrach.ru/jour/article/view/197 |
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| Summary: | Cough is a reflex, protective and adaptive reaction of the body aimed at removing foreign sub-stances and/or pathologically altered tracheobronchial secretions from the respiratory tract. Cough is one of the most important components of pulmonary clearance, which is activated when natural mechanisms fail. It can have both a positive value (clearing the airways) and a negative value (it tires the patient, disrupts sleep, nutrition, and can lead to various complica-tions). Therefore, the treatment of cough using pharmacological and nonmedicinal methods can reduce it in the case of excessive severity and improve pulmonary clearance. The basis of cough pharmacotherapy is mucoactive drugs, which form four pharmacological groups: expectorants, mucolytics, mucokinetics, mucoregulators. In addition, in some cases, drugs can be used to suppress the cough reflex in the central or peripheral link. All of them provide symptomatic cough relief and reduce the duration of symptoms. The choice of medicines for the treatment of cough is determined by their pharmacodynamics and features of influence on the nature of bronchial secretions. |
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| ISSN: | 1560-5175 2687-1181 |