Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions

Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions

ABSTRACT This study explores the virulence mechanisms of Vibrio cholerae, with a particular emphasis on HapA, a zinc metalloprotease delivered via outer membrane vesicles (OMVs). The findings reveal that OMV‐associated HapA disrupts the integrity of tight and adherens junctions in intestinal epithel...

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Bibliographic Details
Main Authors: Palwasha Baryalai, David Irenaeus, Eric Toh, Madeleine Ramstedt, Bernt Eric Uhlin, Aftab Nadeem, Sun Nyunt Wai
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of Extracellular Vesicles
Subjects:
adherens junctions
cholera
outer membrane vesicles
protease
tight junctions
virulence
Online Access:https://doi.org/10.1002/jev2.70092
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https://doi.org/10.1002/jev2.70092

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