Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer
<b>Background and Objectives</b>: The current study aimed to compare the effectiveness of the Lung Imaging Reporting and Data System (Lung-RADS) Version 2022 and the British Thoracic Society (BTS) guidelines in differentiating lung metastases from de novo primary lung cancer on CT scans...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/130 |
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| author | Loredana Gabriela Stana Alexandru Ovidiu Mederle Claudiu Avram Felix Bratosin Paula Irina Barata |
| author_facet | Loredana Gabriela Stana Alexandru Ovidiu Mederle Claudiu Avram Felix Bratosin Paula Irina Barata |
| author_sort | Loredana Gabriela Stana |
| collection | DOAJ |
| description | <b>Background and Objectives</b>: The current study aimed to compare the effectiveness of the Lung Imaging Reporting and Data System (Lung-RADS) Version 2022 and the British Thoracic Society (BTS) guidelines in differentiating lung metastases from de novo primary lung cancer on CT scans in patients without prior cancer diagnosis. <b>Materials and Methods</b>: This retrospective study included 196 patients who underwent chest CT scans between 2015 and 2022 without a known history of cancer but with detected pulmonary nodules. CT images characterized nodules based on size, number, location, margins, attenuation, and growth patterns. Nodules were classified according to Lung-RADS Version 2022 and BTS guidelines. Statistical analyses compared the sensitivity and specificity of Lung-RADS and BTS guidelines in distinguishing metastases from primary lung cancer. Subgroup analyses were conducted based on nodule characteristics. <b>Results</b>: Of the 196 patients, 148 (75.5%) had de novo primary lung cancer, and 48 (24.5%) had lung metastases from occult primary tumors. Lung-RADS Version 2022 demonstrated higher specificity than BTS guidelines (87.2% vs. 72.3%, <i>p</i> < 0.001) while maintaining similar sensitivity (91.7% vs. 93.8%, <i>p</i> = 0.68) in differentiating lung metastases from primary lung cancer. Lung metastases were more likely to present with multiple nodules (81.3% vs. 18.2%, <i>p</i> < 0.001), lower lobe distribution (58.3% vs. 28.4%, <i>p</i> < 0.001), and smooth margins (70.8% vs. 20.3%, <i>p</i> < 0.001), whereas primary lung cancers were associated with solitary nodules, upper lobe location, and spiculated margins. <b>Conclusions</b>: Lung-RADS Version 2022 provides higher specificity than the BTS guidelines in differentiating lung metastases from primary lung cancer on CT scans in patients without prior cancer diagnosis. Recognizing characteristic imaging features can improve diagnostic accuracy and guide appropriate management. |
| format | Article |
| id | doaj-art-9e9faff56ae64ae3839ca658d6cfa04c |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-9e9faff56ae64ae3839ca658d6cfa04c2025-01-24T13:24:07ZengMDPI AGBiomedicines2227-90592025-01-0113113010.3390/biomedicines13010130Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung CancerLoredana Gabriela Stana0Alexandru Ovidiu Mederle1Claudiu Avram2Felix Bratosin3Paula Irina Barata4Department I, Discipline of Anatomy and Embriology, Victor Babes University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Surgery, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDoctoral School, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Infectious Disease, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, RomaniaCenter for Research and Innovation in Precision Medicine of Respiratory Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania<b>Background and Objectives</b>: The current study aimed to compare the effectiveness of the Lung Imaging Reporting and Data System (Lung-RADS) Version 2022 and the British Thoracic Society (BTS) guidelines in differentiating lung metastases from de novo primary lung cancer on CT scans in patients without prior cancer diagnosis. <b>Materials and Methods</b>: This retrospective study included 196 patients who underwent chest CT scans between 2015 and 2022 without a known history of cancer but with detected pulmonary nodules. CT images characterized nodules based on size, number, location, margins, attenuation, and growth patterns. Nodules were classified according to Lung-RADS Version 2022 and BTS guidelines. Statistical analyses compared the sensitivity and specificity of Lung-RADS and BTS guidelines in distinguishing metastases from primary lung cancer. Subgroup analyses were conducted based on nodule characteristics. <b>Results</b>: Of the 196 patients, 148 (75.5%) had de novo primary lung cancer, and 48 (24.5%) had lung metastases from occult primary tumors. Lung-RADS Version 2022 demonstrated higher specificity than BTS guidelines (87.2% vs. 72.3%, <i>p</i> < 0.001) while maintaining similar sensitivity (91.7% vs. 93.8%, <i>p</i> = 0.68) in differentiating lung metastases from primary lung cancer. Lung metastases were more likely to present with multiple nodules (81.3% vs. 18.2%, <i>p</i> < 0.001), lower lobe distribution (58.3% vs. 28.4%, <i>p</i> < 0.001), and smooth margins (70.8% vs. 20.3%, <i>p</i> < 0.001), whereas primary lung cancers were associated with solitary nodules, upper lobe location, and spiculated margins. <b>Conclusions</b>: Lung-RADS Version 2022 provides higher specificity than the BTS guidelines in differentiating lung metastases from primary lung cancer on CT scans in patients without prior cancer diagnosis. Recognizing characteristic imaging features can improve diagnostic accuracy and guide appropriate management.https://www.mdpi.com/2227-9059/13/1/130Lung-RADSBritish Thoracic Society guidelineslung metastasesprimary lung cancerCT imagingpulmonary nodules |
| spellingShingle | Loredana Gabriela Stana Alexandru Ovidiu Mederle Claudiu Avram Felix Bratosin Paula Irina Barata Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer Biomedicines Lung-RADS British Thoracic Society guidelines lung metastases primary lung cancer CT imaging pulmonary nodules |
| title | Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer |
| title_full | Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer |
| title_fullStr | Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer |
| title_full_unstemmed | Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer |
| title_short | Retrospective Analysis Comparing Lung-RADS v2022 and British Thoracic Society Guidelines for Differentiating Lung Metastases from Primary Lung Cancer |
| title_sort | retrospective analysis comparing lung rads v2022 and british thoracic society guidelines for differentiating lung metastases from primary lung cancer |
| topic | Lung-RADS British Thoracic Society guidelines lung metastases primary lung cancer CT imaging pulmonary nodules |
| url | https://www.mdpi.com/2227-9059/13/1/130 |
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