Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis
Background. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/278905 |
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| _version_ | 1832565521003839488 |
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| author | Lin Li Lingling Li Xiaoying Zhou Shuping Xiao Huiyuan Gu Guoxin Zhang |
| author_facet | Lin Li Lingling Li Xiaoying Zhou Shuping Xiao Huiyuan Gu Guoxin Zhang |
| author_sort | Lin Li |
| collection | DOAJ |
| description | Background. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori infection. Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence of H. pylori infection between pregnant women with HG and the normal pregnant control subjects. Results. Of the HG cases, 1289 (69.6%) were H. pylori-positive; however, 1045 (46.2%) were H. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate of H. pylori was significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81, P<0.001). Subgroup analysis indicated that H. pylori infection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54, P<0.001). Conclusions. H. pylori should be considered one of the risk factors of HG, especially in the developing countries. H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases. |
| format | Article |
| id | doaj-art-9e8e2cc771d749ceb0d4380497d2b888 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9e8e2cc771d749ceb0d4380497d2b8882025-02-03T01:07:24ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/278905278905Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-AnalysisLin Li0Lingling Li1Xiaoying Zhou2Shuping Xiao3Huiyuan Gu4Guoxin Zhang5Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaFirst Clinical Medical College, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaBackground. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori infection. Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence of H. pylori infection between pregnant women with HG and the normal pregnant control subjects. Results. Of the HG cases, 1289 (69.6%) were H. pylori-positive; however, 1045 (46.2%) were H. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate of H. pylori was significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81, P<0.001). Subgroup analysis indicated that H. pylori infection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54, P<0.001). Conclusions. H. pylori should be considered one of the risk factors of HG, especially in the developing countries. H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.http://dx.doi.org/10.1155/2015/278905 |
| spellingShingle | Lin Li Lingling Li Xiaoying Zhou Shuping Xiao Huiyuan Gu Guoxin Zhang Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis Gastroenterology Research and Practice |
| title | Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis |
| title_full | Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis |
| title_fullStr | Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis |
| title_full_unstemmed | Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis |
| title_short | Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis |
| title_sort | helicobacter pylori infection is associated with an increased risk of hyperemesis gravidarum a meta analysis |
| url | http://dx.doi.org/10.1155/2015/278905 |
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