Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease
The accuracy of the 13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the 13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/235796 |
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| author | Hamizah Razlan Nurhayaty Muhamad Marzuki Mei-Ling Sharon Tai Azhar-Shah Shamsul Tze-Zen Ong Sanjiv Mahadeva |
| author_facet | Hamizah Razlan Nurhayaty Muhamad Marzuki Mei-Ling Sharon Tai Azhar-Shah Shamsul Tze-Zen Ong Sanjiv Mahadeva |
| author_sort | Hamizah Razlan |
| collection | DOAJ |
| description | The accuracy of the 13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the 13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50±16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The 13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis. |
| format | Article |
| id | doaj-art-9e80c6241cd244b9afe1cc90b0549a66 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9e80c6241cd244b9afe1cc90b0549a662025-02-03T05:52:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2011-01-01201110.1155/2011/235796235796Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver DiseaseHamizah Razlan0Nurhayaty Muhamad Marzuki1Mei-Ling Sharon Tai2Azhar-Shah Shamsul3Tze-Zen Ong4Sanjiv Mahadeva5Department of Medicine, Faculty of Medicine, University Kebangsaan Malaysia, 56000 Kuala Lumpur, MalaysiaDepartment of Medicine, Faculty of Medicine, University Kebangsaan Malaysia, 56000 Kuala Lumpur, MalaysiaDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Community Health, Faculty of Medicine, University Kebangsaan Malaysia, 56000 Kuala Lumpur, MalaysiaSentosa Kajang Medical Centre, 43000 Kajang, Selangor, MalaysiaDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaThe accuracy of the 13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the 13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50±16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The 13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis.http://dx.doi.org/10.1155/2011/235796 |
| spellingShingle | Hamizah Razlan Nurhayaty Muhamad Marzuki Mei-Ling Sharon Tai Azhar-Shah Shamsul Tze-Zen Ong Sanjiv Mahadeva Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease Gastroenterology Research and Practice |
| title | Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
| title_full | Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
| title_fullStr | Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
| title_full_unstemmed | Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
| title_short | Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
| title_sort | diagnostic value of the 13c methacetin breath test in various stages of chronic liver disease |
| url | http://dx.doi.org/10.1155/2011/235796 |
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