B cells and tertiary lymphoid structures in cancer therapy response
Abstract Recent advances in immuno-oncology research have revolutionised our understanding of the interplay between immune cells and the tumour microenvironment (TME), profoundly impacting patient responses to therapy. The TME, comprising tumour cells, immune cells, extracellular matrix, stromal cel...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | BJC Reports |
| Online Access: | https://doi.org/10.1038/s44276-025-00146-1 |
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| author | Adèle Hegoburu Mohammad Amer Frank Frizelle Rachel Purcell |
| author_facet | Adèle Hegoburu Mohammad Amer Frank Frizelle Rachel Purcell |
| author_sort | Adèle Hegoburu |
| collection | DOAJ |
| description | Abstract Recent advances in immuno-oncology research have revolutionised our understanding of the interplay between immune cells and the tumour microenvironment (TME), profoundly impacting patient responses to therapy. The TME, comprising tumour cells, immune cells, extracellular matrix, stromal cells, and co-existing microbes, orchestrates the immune phenotype of cancers, shaping disease progression and treatment outcomes. Immune-cell infiltration serves as a significant prognostic marker in various cancers, with higher rates correlating with improved prognosis. Recent discoveries have paved the way for immune checkpoint blockade therapies, which exhibit remarkable efficacy across multiple cancer types. However, understanding the nuanced contributions of different immune-cell populations to therapeutic responses remains a challenge. The majority of research has focussed on the role of T cells in the immune response to cancer therapies, with the potential importance of B cells only recently being recognised. Here, we review the diverse phenotypes of B cells within the TME, their structural organisation within tertiary lymphoid structures (TLS), and the role of both B cells and TLS in cancer prognosis and response to different therapies for cancer treatment. |
| format | Article |
| id | doaj-art-9e7f5e83e1634561ba953e6d2115c0d9 |
| institution | DOAJ |
| issn | 2731-9377 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | BJC Reports |
| spelling | doaj-art-9e7f5e83e1634561ba953e6d2115c0d92025-08-20T03:22:01ZengNature PortfolioBJC Reports2731-93772025-05-01311710.1038/s44276-025-00146-1B cells and tertiary lymphoid structures in cancer therapy responseAdèle Hegoburu0Mohammad Amer1Frank Frizelle2Rachel Purcell3Department of Surgery and Critical Care, Ōtākou Whakaihu Waka/University of OtagoDepartment of Surgery and Critical Care, Ōtākou Whakaihu Waka/University of OtagoDepartment of Surgery and Critical Care, Ōtākou Whakaihu Waka/University of OtagoDepartment of Surgery and Critical Care, Ōtākou Whakaihu Waka/University of OtagoAbstract Recent advances in immuno-oncology research have revolutionised our understanding of the interplay between immune cells and the tumour microenvironment (TME), profoundly impacting patient responses to therapy. The TME, comprising tumour cells, immune cells, extracellular matrix, stromal cells, and co-existing microbes, orchestrates the immune phenotype of cancers, shaping disease progression and treatment outcomes. Immune-cell infiltration serves as a significant prognostic marker in various cancers, with higher rates correlating with improved prognosis. Recent discoveries have paved the way for immune checkpoint blockade therapies, which exhibit remarkable efficacy across multiple cancer types. However, understanding the nuanced contributions of different immune-cell populations to therapeutic responses remains a challenge. The majority of research has focussed on the role of T cells in the immune response to cancer therapies, with the potential importance of B cells only recently being recognised. Here, we review the diverse phenotypes of B cells within the TME, their structural organisation within tertiary lymphoid structures (TLS), and the role of both B cells and TLS in cancer prognosis and response to different therapies for cancer treatment.https://doi.org/10.1038/s44276-025-00146-1 |
| spellingShingle | Adèle Hegoburu Mohammad Amer Frank Frizelle Rachel Purcell B cells and tertiary lymphoid structures in cancer therapy response BJC Reports |
| title | B cells and tertiary lymphoid structures in cancer therapy response |
| title_full | B cells and tertiary lymphoid structures in cancer therapy response |
| title_fullStr | B cells and tertiary lymphoid structures in cancer therapy response |
| title_full_unstemmed | B cells and tertiary lymphoid structures in cancer therapy response |
| title_short | B cells and tertiary lymphoid structures in cancer therapy response |
| title_sort | b cells and tertiary lymphoid structures in cancer therapy response |
| url | https://doi.org/10.1038/s44276-025-00146-1 |
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