Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis
A 45-year-old obese man presented with persistent hematuria for 21 years. At the age of 37, he developed hypertension and proteinuria which later increased up to 1.6 g/g creatinine. Kidney biopsy revealed thin basement membrane nephropathy (TBMN) and focal segmental glomerulosclerosis (FSGS), which...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2019/1627392 |
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| author | Ryo Togashi Yoshikazu Nemoto Kaito Waki Michito Nagura Shigeyuki Arai Yoshifuru Tamura Yasutoshi Oshima Fukuo Kondo Ryuji Ohashi Shunya Uchida Shigeru Shibata Yoshihide Fujigaki |
| author_facet | Ryo Togashi Yoshikazu Nemoto Kaito Waki Michito Nagura Shigeyuki Arai Yoshifuru Tamura Yasutoshi Oshima Fukuo Kondo Ryuji Ohashi Shunya Uchida Shigeru Shibata Yoshihide Fujigaki |
| author_sort | Ryo Togashi |
| collection | DOAJ |
| description | A 45-year-old obese man presented with persistent hematuria for 21 years. At the age of 37, he developed hypertension and proteinuria which later increased up to 1.6 g/g creatinine. Kidney biopsy revealed thin basement membrane nephropathy (TBMN) and focal segmental glomerulosclerosis (FSGS), which explained his urinary abnormalities. Although a subgroup of TBMN can be complicated by FSGS, his FSGS was associated with obesity because of its histological features. Reduction of body weight and increasing a dose of angiotensin-receptor blocker could transiently reduce the amount of proteinuria. Clinicopathological implications of proteinuria after long-term hematuria by TBMN and FSGS were further discussed. |
| format | Article |
| id | doaj-art-9e74d93ef59c4331b8c4e949647a8864 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-9e74d93ef59c4331b8c4e949647a88642025-02-03T01:20:28ZengWileyCase Reports in Nephrology2090-66412090-665X2019-01-01201910.1155/2019/16273921627392Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental GlomerulosclerosisRyo Togashi0Yoshikazu Nemoto1Kaito Waki2Michito Nagura3Shigeyuki Arai4Yoshifuru Tamura5Yasutoshi Oshima6Fukuo Kondo7Ryuji Ohashi8Shunya Uchida9Shigeru Shibata10Yoshihide Fujigaki11Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Pathology, Teikyo University Hospital, Itabashi-ku, Tokyo, JapanDepartment of Pathology, Teikyo University Hospital, Itabashi-ku, Tokyo, JapanDepartment of Diagnostic Pathology, Nippon Medical School Musashikosugi Hospital, Kasasaki-City, Kanagawa, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, JapanA 45-year-old obese man presented with persistent hematuria for 21 years. At the age of 37, he developed hypertension and proteinuria which later increased up to 1.6 g/g creatinine. Kidney biopsy revealed thin basement membrane nephropathy (TBMN) and focal segmental glomerulosclerosis (FSGS), which explained his urinary abnormalities. Although a subgroup of TBMN can be complicated by FSGS, his FSGS was associated with obesity because of its histological features. Reduction of body weight and increasing a dose of angiotensin-receptor blocker could transiently reduce the amount of proteinuria. Clinicopathological implications of proteinuria after long-term hematuria by TBMN and FSGS were further discussed.http://dx.doi.org/10.1155/2019/1627392 |
| spellingShingle | Ryo Togashi Yoshikazu Nemoto Kaito Waki Michito Nagura Shigeyuki Arai Yoshifuru Tamura Yasutoshi Oshima Fukuo Kondo Ryuji Ohashi Shunya Uchida Shigeru Shibata Yoshihide Fujigaki Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis Case Reports in Nephrology |
| title | Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis |
| title_full | Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis |
| title_fullStr | Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis |
| title_full_unstemmed | Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis |
| title_short | Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis |
| title_sort | clinicopathological implications of proteinuria after long term isolated hematuria due to thin basement membrane nephropathy and focal segmental glomerulosclerosis |
| url | http://dx.doi.org/10.1155/2019/1627392 |
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