Extracellular vesicle-derived miRNA-mediated cell–cell communication inference for single-cell transcriptomic data with miRTalk

Extracellular vesicle-derived miRNA-mediated cell–cell communication inference for single-cell transcriptomic data with miRTalk

Abstract MicroRNAs are released from cells in extracellular vesicles (EVs), representing an essential mode of cell–cell communication (CCC) via a regulatory effect on gene expression. Single-cell RNA-sequencing technologies have ushered in an era of elucidating CCC at single-cell resolution. Herein,...

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Bibliographic Details
Main Authors: Xin Shao, Lingqi Yu, Chengyu Li, Jingyang Qian, Xinyu Yang, Haihong Yang, Jie Liao, Xueru Fan, Xiao Xu, Xiaohui Fan
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Biology
Subjects:
Cell–cell communication
Extracellular vesicle
MiRNA
ScRNA-seq
Spatial transcriptomics
Online Access:https://doi.org/10.1186/s13059-025-03566-x
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