Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola
A polyketide known as cladospolide B, (Z)-4,5-dihydroxy-2-dodecen-11-olide was isolated from the culture broth of the fungus, Lambertella brunneola. The structure elucidation of this compound was based on Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS) analyses. Clados...
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Davao Oriental State University
2012-12-01
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| Series: | Davao Research Journal |
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| Online Access: | https://davaoresearchjournal.ph/index.php/main/article/view/34 |
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| author | Wilanfranco Tayone Noboru Takada |
| author_facet | Wilanfranco Tayone Noboru Takada |
| author_sort | Wilanfranco Tayone |
| collection | DOAJ |
| description | A polyketide known as cladospolide B, (Z)-4,5-dihydroxy-2-dodecen-11-olide was isolated from the culture broth of the fungus, Lambertella brunneola. The structure elucidation of this compound was based on Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS) analyses. Cladospolide B exhibited a seemingly weak antifungal activity and inhibited the hyphalgrowth of the phyto-pathogenicfungus, Helminthosporium oryzae(=Cochliobolus miyabeanus) by 50 % at more than 1 mg/mL but less than 5 mg/mL (1 < IC50 <5). This is the first report on the isolation of cladospolide B from L. brunneola. |
| format | Article |
| id | doaj-art-9e64bcdfd5a6453b8a9f8b81a5fcbd16 |
| institution | OA Journals |
| issn | 2244-4432 2984-7125 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | Davao Oriental State University |
| record_format | Article |
| series | Davao Research Journal |
| spelling | doaj-art-9e64bcdfd5a6453b8a9f8b81a5fcbd162025-08-20T01:55:18ZengDavao Oriental State UniversityDavao Research Journal2244-44322984-71252012-12-0181101410.59120/drj.v8i1.3434Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneolaWilanfranco Tayone0Noboru Takada1Asst. Professor, Mathematics and Natural Sciences Department, Davao Oriental State College of Science & TechnologyAsso. Professor, Faculty of Agriculture and Life Science, Hirosaki UniversityA polyketide known as cladospolide B, (Z)-4,5-dihydroxy-2-dodecen-11-olide was isolated from the culture broth of the fungus, Lambertella brunneola. The structure elucidation of this compound was based on Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS) analyses. Cladospolide B exhibited a seemingly weak antifungal activity and inhibited the hyphalgrowth of the phyto-pathogenicfungus, Helminthosporium oryzae(=Cochliobolus miyabeanus) by 50 % at more than 1 mg/mL but less than 5 mg/mL (1 < IC50 <5). This is the first report on the isolation of cladospolide B from L. brunneola.https://davaoresearchjournal.ph/index.php/main/article/view/34cladospolide b antifungalchromatographynuclear magnetic resonance (nmr)structure elucidation |
| spellingShingle | Wilanfranco Tayone Noboru Takada Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola Davao Research Journal cladospolide b antifungal chromatography nuclear magnetic resonance (nmr) structure elucidation |
| title | Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola |
| title_full | Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola |
| title_fullStr | Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola |
| title_full_unstemmed | Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola |
| title_short | Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola |
| title_sort | cladospolide b an antifungal polyketide isolated from the fungus lambertella brunneola |
| topic | cladospolide b antifungal chromatography nuclear magnetic resonance (nmr) structure elucidation |
| url | https://davaoresearchjournal.ph/index.php/main/article/view/34 |
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