Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer

Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer

IntroductionIdentification of effective therapies for colorectal cancer (CRC) remains an urgent medical need, especially for the microsatellite stable (MSS) phenotype. In our previous study, potassium oxonate (PO), a uricase inhibitor commonly used for elevating uric acid in mice, unexpectedly showe...

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Bibliographic Details
Main Authors: Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Oncology
Subjects:
anti-PD-1
CRC
immunotherapy
immune microenvironment
potassium oxonate
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1528004/full
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