The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery
Introduction. Cell salvaging is well established in the blood management of cardiac patients, but there remain some concerns about its effects on perioperative bleeding and transfusion variables. This randomized controlled study investigated the potential effects of the centrifuged end-product on bl...
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Wiley
2022-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/3993452 |
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| author | Frixos Tachias Evangelia Samara Anastasios Petrou Agathi Karakosta Stavros Siminelakis Efstratios Apostolakis Petros Tzimas |
| author_facet | Frixos Tachias Evangelia Samara Anastasios Petrou Agathi Karakosta Stavros Siminelakis Efstratios Apostolakis Petros Tzimas |
| author_sort | Frixos Tachias |
| collection | DOAJ |
| description | Introduction. Cell salvaging is well established in the blood management of cardiac patients, but there remain some concerns about its effects on perioperative bleeding and transfusion variables. This randomized controlled study investigated the potential effects of the centrifuged end-product on bleeding, transfusion rates, and other transfusion-related variables in adult cardiac surgery patients submitted to extracorporeal circulation. Materials and Methods. Patients were randomly chosen to receive (cell-salvage group, 99 patients) or not to receive (control group, 110 patients) the centrifuged product of a cell salvage apparatus. Bleeding and transfusion rates according to the universal definition of perioperative bleeding (UDPB) classification, postoperative hemoglobin, coagulation, and oxygenation indices were recorded and compared between the groups. Results. Both groups had almost identical bleeding and transfusion rates (median value: 2 units of red blood cells (RBC) and no units of fresh frozen plasma (FFP) and platelets (PLT) for both groups, p>0.05). Patients in the cell-salvage group presented slightly higher hemoglobin concentrations (10.6 ± 1.1 vs. 10.1 ± 1.7 g/dL, p<0.05, respectively) and a tendency towards better oxygenation indices (PaO2/FiO2: 241 ± 94 vs. 207 ± 84, p=0.013) in the postoperative period albeit with a tendency for prolongation of prothrombin time (INR: 1.31 ± 0.18 vs. 1.26 ± 0.12, p=0.008). Conclusion. Within the study’s constraints, the perioperative use of the cell salvage concentrate does not seem to affect bleeding or transfusion variables, although it could probably ameliorate postoperative oxygenation in adult cardiac surgery patients. A tendency to promote coagulation disturbances was detected. |
| format | Article |
| id | doaj-art-9e4c11064c3f43ca8417b9649c277687 |
| institution | Kabale University |
| issn | 1687-6970 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-9e4c11064c3f43ca8417b9649c2776872025-02-03T05:57:23ZengWileyAnesthesiology Research and Practice1687-69702022-01-01202210.1155/2022/3993452The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac SurgeryFrixos Tachias0Evangelia Samara1Anastasios Petrou2Agathi Karakosta3Stavros Siminelakis4Efstratios Apostolakis5Petros Tzimas6Department of Anesthesiology and Postoperative Intensive CareDepartment of Anesthesiology and Postoperative Intensive CareDepartment of AnesthesiologyDepartment of Anesthesiology and Postoperative Intensive CareDepartment of Cardiothoracic SurgeryDepartment of Cardiothoracic SurgeryDepartment of Anesthesiology and Postoperative Intensive CareIntroduction. Cell salvaging is well established in the blood management of cardiac patients, but there remain some concerns about its effects on perioperative bleeding and transfusion variables. This randomized controlled study investigated the potential effects of the centrifuged end-product on bleeding, transfusion rates, and other transfusion-related variables in adult cardiac surgery patients submitted to extracorporeal circulation. Materials and Methods. Patients were randomly chosen to receive (cell-salvage group, 99 patients) or not to receive (control group, 110 patients) the centrifuged product of a cell salvage apparatus. Bleeding and transfusion rates according to the universal definition of perioperative bleeding (UDPB) classification, postoperative hemoglobin, coagulation, and oxygenation indices were recorded and compared between the groups. Results. Both groups had almost identical bleeding and transfusion rates (median value: 2 units of red blood cells (RBC) and no units of fresh frozen plasma (FFP) and platelets (PLT) for both groups, p>0.05). Patients in the cell-salvage group presented slightly higher hemoglobin concentrations (10.6 ± 1.1 vs. 10.1 ± 1.7 g/dL, p<0.05, respectively) and a tendency towards better oxygenation indices (PaO2/FiO2: 241 ± 94 vs. 207 ± 84, p=0.013) in the postoperative period albeit with a tendency for prolongation of prothrombin time (INR: 1.31 ± 0.18 vs. 1.26 ± 0.12, p=0.008). Conclusion. Within the study’s constraints, the perioperative use of the cell salvage concentrate does not seem to affect bleeding or transfusion variables, although it could probably ameliorate postoperative oxygenation in adult cardiac surgery patients. A tendency to promote coagulation disturbances was detected.http://dx.doi.org/10.1155/2022/3993452 |
| spellingShingle | Frixos Tachias Evangelia Samara Anastasios Petrou Agathi Karakosta Stavros Siminelakis Efstratios Apostolakis Petros Tzimas The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery Anesthesiology Research and Practice |
| title | The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery |
| title_full | The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery |
| title_fullStr | The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery |
| title_full_unstemmed | The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery |
| title_short | The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery |
| title_sort | effect of cell salvage on bleeding and transfusion needs in cardiac surgery |
| url | http://dx.doi.org/10.1155/2022/3993452 |
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