Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential
Abstract In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human cancers is increasing. These peptides r...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Hematology & Oncology |
| Online Access: | https://doi.org/10.1186/s13045-025-01671-9 |
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| _version_ | 1850190684250701824 |
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| author | Shiming Tan Wenjuan Yang Zongyao Ren Qiu Peng Xuemeng Xu Xianjie Jiang Zhu Wu Linda Oyang Xia Luo Jinguan Lin Longzheng Xia Mingjing Peng Nayiyuan Wu Yanyan Tang Yaqian Han Qianjin Liao Yujuan Zhou |
| author_facet | Shiming Tan Wenjuan Yang Zongyao Ren Qiu Peng Xuemeng Xu Xianjie Jiang Zhu Wu Linda Oyang Xia Luo Jinguan Lin Longzheng Xia Mingjing Peng Nayiyuan Wu Yanyan Tang Yaqian Han Qianjin Liao Yujuan Zhou |
| author_sort | Shiming Tan |
| collection | DOAJ |
| description | Abstract In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human cancers is increasing. These peptides regulate cancer progression through multiple molecular mechanisms. Here, we delineate the patterns of diverse ncRNA-encoded peptides and provide a synopsis of the methodologies employed for the identification of ncRNAs that possess the capacity to encode these peptides. Furthermore, we discuss the impacts of ncRNA-encoded peptides on the biological behavior of cancer cells and the underlying molecular mechanisms. In conclusion, we describe the prospects of ncRNA-encoded peptides in cancer and the challenges that need to be overcome. |
| format | Article |
| id | doaj-art-9e3d5a42e0d342a1b8eef9e6b968eac9 |
| institution | OA Journals |
| issn | 1756-8722 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj-art-9e3d5a42e0d342a1b8eef9e6b968eac92025-08-20T02:15:12ZengBMCJournal of Hematology & Oncology1756-87222025-02-0118112910.1186/s13045-025-01671-9Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potentialShiming Tan0Wenjuan Yang1Zongyao Ren2Qiu Peng3Xuemeng Xu4Xianjie Jiang5Zhu Wu6Linda Oyang7Xia Luo8Jinguan Lin9Longzheng Xia10Mingjing Peng11Nayiyuan Wu12Yanyan Tang13Yaqian Han14Qianjin Liao15Yujuan Zhou16The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismDepartment of Oncology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer MetabolismAbstract In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human cancers is increasing. These peptides regulate cancer progression through multiple molecular mechanisms. Here, we delineate the patterns of diverse ncRNA-encoded peptides and provide a synopsis of the methodologies employed for the identification of ncRNAs that possess the capacity to encode these peptides. Furthermore, we discuss the impacts of ncRNA-encoded peptides on the biological behavior of cancer cells and the underlying molecular mechanisms. In conclusion, we describe the prospects of ncRNA-encoded peptides in cancer and the challenges that need to be overcome.https://doi.org/10.1186/s13045-025-01671-9 |
| spellingShingle | Shiming Tan Wenjuan Yang Zongyao Ren Qiu Peng Xuemeng Xu Xianjie Jiang Zhu Wu Linda Oyang Xia Luo Jinguan Lin Longzheng Xia Mingjing Peng Nayiyuan Wu Yanyan Tang Yaqian Han Qianjin Liao Yujuan Zhou Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential Journal of Hematology & Oncology |
| title | Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential |
| title_full | Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential |
| title_fullStr | Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential |
| title_full_unstemmed | Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential |
| title_short | Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential |
| title_sort | noncoding rna encoded peptides in cancer biological functions posttranslational modifications and therapeutic potential |
| url | https://doi.org/10.1186/s13045-025-01671-9 |
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