Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects
Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevan...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/680853 |
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| _version_ | 1832565114329366528 |
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| author | Weijie Wang Donghua Xu Bin Wang Shushan Yan Xiaochen Wang Yin Yin Xuehao Wang Beicheng Sun Xiaoyang Sun |
| author_facet | Weijie Wang Donghua Xu Bin Wang Shushan Yan Xiaochen Wang Yin Yin Xuehao Wang Beicheng Sun Xiaoyang Sun |
| author_sort | Weijie Wang |
| collection | DOAJ |
| description | Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases from their inception up to July 1, 2014, was performed to identify eligible studies. The strength for relationship between gout and the risk of different cancers was evaluated by calculating pooled relative risks (RRs) with 95% confidence intervals (95% CIs). All analyses were carried out by STATA 12.0 software. Gout patients were at an increased risk of cancer, particularly urological cancers, digestive system cancers, and lung cancer. No such significant association between gout and the risk of breast or brain cancers was observed. Sensitivity analysis did not materially alter the pooled results. Gout is a risk factor of cancer, particularly that of urological cancers, digestive system cancers, and lung cancer. The pooled data further support the hypothesis of a link between gout and carcinogenesis. |
| format | Article |
| id | doaj-art-9e3027eaea0c488284db0bab9823f605 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9e3027eaea0c488284db0bab9823f6052025-02-03T01:09:22ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/680853680853Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 SubjectsWeijie Wang0Donghua Xu1Bin Wang2Shushan Yan3Xiaochen Wang4Yin Yin5Xuehao Wang6Beicheng Sun7Xiaoyang Sun8Department of Neurosurgery, Huai’an First People’s Hospital Affiliated to Nanjing Medical University, 6 Beijing Road West, Huai’an 223300, ChinaDepartment of Rheumatology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, ChinaLiver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, ChinaLiver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, ChinaLiver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, ChinaLiver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, ChinaLiver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, ChinaDepartment of Neurosurgery, Huai’an First People’s Hospital Affiliated to Nanjing Medical University, 6 Beijing Road West, Huai’an 223300, ChinaGout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases from their inception up to July 1, 2014, was performed to identify eligible studies. The strength for relationship between gout and the risk of different cancers was evaluated by calculating pooled relative risks (RRs) with 95% confidence intervals (95% CIs). All analyses were carried out by STATA 12.0 software. Gout patients were at an increased risk of cancer, particularly urological cancers, digestive system cancers, and lung cancer. No such significant association between gout and the risk of breast or brain cancers was observed. Sensitivity analysis did not materially alter the pooled results. Gout is a risk factor of cancer, particularly that of urological cancers, digestive system cancers, and lung cancer. The pooled data further support the hypothesis of a link between gout and carcinogenesis.http://dx.doi.org/10.1155/2015/680853 |
| spellingShingle | Weijie Wang Donghua Xu Bin Wang Shushan Yan Xiaochen Wang Yin Yin Xuehao Wang Beicheng Sun Xiaoyang Sun Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects Mediators of Inflammation |
| title | Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects |
| title_full | Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects |
| title_fullStr | Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects |
| title_full_unstemmed | Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects |
| title_short | Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects |
| title_sort | increased risk of cancer in relation to gout a review of three prospective cohort studies with 50 358 subjects |
| url | http://dx.doi.org/10.1155/2015/680853 |
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