An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition
Abstract Background Among cancer patients, pancreatic cancer patients have the highest rate of sarcopenia, which is a critical prognostic factor. Serum creatine kinase (CK) is closely related to skeletal muscle mass and has been reported to decline with the progression of cancer. This study investig...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Nutrition Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12937-025-01084-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832572020631535616 |
|---|---|
| author | Cong Chen Xin Luo Xianchao Lin Ronggui Lin Yuanyuan Yang Congfei Wang Haizong Fang Tianhong Teng Heguang Huang Fengchun Lu |
| author_facet | Cong Chen Xin Luo Xianchao Lin Ronggui Lin Yuanyuan Yang Congfei Wang Haizong Fang Tianhong Teng Heguang Huang Fengchun Lu |
| author_sort | Cong Chen |
| collection | DOAJ |
| description | Abstract Background Among cancer patients, pancreatic cancer patients have the highest rate of sarcopenia, which is a critical prognostic factor. Serum creatine kinase (CK) is closely related to skeletal muscle mass and has been reported to decline with the progression of cancer. This study investigated whether preoperative serum CK is associated with the survival of patients with pancreatic cancer. Methods Data were obtained from patients with pathologically confirmed pancreatic cancer between June 2016 and March 2022. The prognostic significance of CK was analyzed based on sex-stratified groups. The Kaplan-Meier method was used to compare overall survival (OS) and disease-free survival (DFS). Multivariate Cox proportional hazards models were used to determine prognostic factors. Body composition was analyzed based on preoperative abdominal CT images to explore the sex-specific associations between skeletal muscle area (SMA) and serum CK levels. Results A total of 166 patients were included in this study. Sarcopenia was presented in 70 patients (42.2%). A low serum CK level showed a significant correlation with the diagnosis of sarcopenia in male patients (P = 0.026). The levels of CK did not predict the outcome in female patients, while a low preoperative CK was notably linked to shorter OS in male patients (median OS: 15 months vs. 33 months, P = 0.011; median DFS: 5 months vs. 14 months, P = 0.007). Multivariate analyses further confirmed the effect of CK in predicting OS (CK>44 IU/L, HR:0.226, 95% CI:0.107–0.478, P < 0.001) and DFS (CK>44 IU/L, HR:0.272, 95% CI:0.139–0.529, P < 0.001) of male patients. Correlation analysis revealed a significant association between SMA and CK levels in male patients (r = 0.225, P = 0.025), and such a correlation was not observed in female patients (r = 0.088, P = 0.478). Conclusion The pretherapeutic CK may represent a simple marker for predicting poor survival in male patients with resectable pancreatic cancer, thereby aiding in the selection of therapeutic strategies. |
| format | Article |
| id | doaj-art-9e2564d0755a4f95833f6f79d770a826 |
| institution | Kabale University |
| issn | 1475-2891 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj-art-9e2564d0755a4f95833f6f79d770a8262025-02-02T12:10:00ZengBMCNutrition Journal1475-28912025-02-0124111110.1186/s12937-025-01084-xAn exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body compositionCong Chen0Xin Luo1Xianchao Lin2Ronggui Lin3Yuanyuan Yang4Congfei Wang5Haizong Fang6Tianhong Teng7Heguang Huang8Fengchun Lu9Department of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalAbstract Background Among cancer patients, pancreatic cancer patients have the highest rate of sarcopenia, which is a critical prognostic factor. Serum creatine kinase (CK) is closely related to skeletal muscle mass and has been reported to decline with the progression of cancer. This study investigated whether preoperative serum CK is associated with the survival of patients with pancreatic cancer. Methods Data were obtained from patients with pathologically confirmed pancreatic cancer between June 2016 and March 2022. The prognostic significance of CK was analyzed based on sex-stratified groups. The Kaplan-Meier method was used to compare overall survival (OS) and disease-free survival (DFS). Multivariate Cox proportional hazards models were used to determine prognostic factors. Body composition was analyzed based on preoperative abdominal CT images to explore the sex-specific associations between skeletal muscle area (SMA) and serum CK levels. Results A total of 166 patients were included in this study. Sarcopenia was presented in 70 patients (42.2%). A low serum CK level showed a significant correlation with the diagnosis of sarcopenia in male patients (P = 0.026). The levels of CK did not predict the outcome in female patients, while a low preoperative CK was notably linked to shorter OS in male patients (median OS: 15 months vs. 33 months, P = 0.011; median DFS: 5 months vs. 14 months, P = 0.007). Multivariate analyses further confirmed the effect of CK in predicting OS (CK>44 IU/L, HR:0.226, 95% CI:0.107–0.478, P < 0.001) and DFS (CK>44 IU/L, HR:0.272, 95% CI:0.139–0.529, P < 0.001) of male patients. Correlation analysis revealed a significant association between SMA and CK levels in male patients (r = 0.225, P = 0.025), and such a correlation was not observed in female patients (r = 0.088, P = 0.478). Conclusion The pretherapeutic CK may represent a simple marker for predicting poor survival in male patients with resectable pancreatic cancer, thereby aiding in the selection of therapeutic strategies.https://doi.org/10.1186/s12937-025-01084-xPancreatic cancerCreatine kinasePrognosisSerum biomarker |
| spellingShingle | Cong Chen Xin Luo Xianchao Lin Ronggui Lin Yuanyuan Yang Congfei Wang Haizong Fang Tianhong Teng Heguang Huang Fengchun Lu An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition Nutrition Journal Pancreatic cancer Creatine kinase Prognosis Serum biomarker |
| title | An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition |
| title_full | An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition |
| title_fullStr | An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition |
| title_full_unstemmed | An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition |
| title_short | An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition |
| title_sort | exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer looking into the relationship with body composition |
| topic | Pancreatic cancer Creatine kinase Prognosis Serum biomarker |
| url | https://doi.org/10.1186/s12937-025-01084-x |
| work_keys_str_mv | AT congchen anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT xinluo anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT xianchaolin anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT rongguilin anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT yuanyuanyang anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT congfeiwang anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT haizongfang anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT tianhongteng anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT heguanghuang anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT fengchunlu anexploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT congchen exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT xinluo exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT xianchaolin exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT rongguilin exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT yuanyuanyang exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT congfeiwang exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT haizongfang exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT tianhongteng exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT heguanghuang exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition AT fengchunlu exploratorystudyofserumcreatinekinaseasaprognosticmarkerforpatientswithresectablepancreaticcancerlookingintotherelationshipwithbodycomposition |