Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin
Objective: Diabetic retinopathy is a common diabetic microvascular problem. Its diagnosis and classification are based on visible changes in clinical fundus examination. However, the discovery of possible vitreous biomarkers in patients with proliferative and nonproliferative diabetic retinopathy ma...
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| Format: | Article |
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Galenos Publishing House
2022-12-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-10270 |
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| author | Burak BILGIN Mete GULER Hulya CICEK Selma URFALIOGLU Gokhan KOKUSARI Bedia MARANGOZOGLU SAHIN |
| author_facet | Burak BILGIN Mete GULER Hulya CICEK Selma URFALIOGLU Gokhan KOKUSARI Bedia MARANGOZOGLU SAHIN |
| author_sort | Burak BILGIN |
| collection | DOAJ |
| description | Objective: Diabetic retinopathy is a common diabetic microvascular problem. Its diagnosis and classification are based on visible changes in clinical fundus examination. However, the discovery of possible vitreous biomarkers in patients with proliferative and nonproliferative diabetic retinopathy may guide both the differentiation and degree of retinopathy. Biomarkers that will be accepted can be also a treatment target. Amphiregulin (AREG) promotes proliferative and regenerative activity and repairs most cell types by binding and activating epidermal growth factor receptors. Progranulin (PGRN) has complex functions in many physiological and pathological processes. Thus, this study aimed to report vitreous AREG and PGRN levels in patients with diabetes and proliferative retinopathy and compare the results with those without diabetes.
Methods: Thirty-three eyes of 33 patients with proliferative diabetic retinopathy and 31 eyes of 31 patients without diabetes were included in this study. Vitreous humor samples were collected from all patients at the time of pars plana vitrectomy surgery immediately before the surgical procedure. Vitreous AREG and PGRN values were determined by the ELISA method.
Results: The mean AREG and PGRN values were similar in the groups (p=0.427, p=0.459, respectively).
Conclusions: The results demonstrated that vitreous AREG and PGRN levels have no significant relationship with proliferative diabetic retinopathy. |
| format | Article |
| id | doaj-art-9e104e47377c438db3c487ebc63eb04d |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-9e104e47377c438db3c487ebc63eb04d2025-01-30T07:07:34ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062022-12-0137432733110.4274/MMJ.galenos.2022.10270MEDJ-10270Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and ProgranulinBurak BILGIN0Mete GULER1Hulya CICEK2Selma URFALIOGLU3Gokhan KOKUSARI4Bedia MARANGOZOGLU SAHIN5Kahramanmaras Sutcu Imam University Faculty of Medicine, Department of Ophthalmology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University Faculty of Medicine, Department of Ophthalmology, Kahramanmaras, TurkeyGaziantep University Faculty of Medicine, Department of Medical Biochemistry, Gaziantep, TurkeyKahramanmaras Sutcu Imam University Faculty of Medicine, Department of Ophthalmology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University Faculty of Medicine, Department of Ophthalmology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University Faculty of Medicine, Department of Ophthalmology, Kahramanmaras, TurkeyObjective: Diabetic retinopathy is a common diabetic microvascular problem. Its diagnosis and classification are based on visible changes in clinical fundus examination. However, the discovery of possible vitreous biomarkers in patients with proliferative and nonproliferative diabetic retinopathy may guide both the differentiation and degree of retinopathy. Biomarkers that will be accepted can be also a treatment target. Amphiregulin (AREG) promotes proliferative and regenerative activity and repairs most cell types by binding and activating epidermal growth factor receptors. Progranulin (PGRN) has complex functions in many physiological and pathological processes. Thus, this study aimed to report vitreous AREG and PGRN levels in patients with diabetes and proliferative retinopathy and compare the results with those without diabetes. Methods: Thirty-three eyes of 33 patients with proliferative diabetic retinopathy and 31 eyes of 31 patients without diabetes were included in this study. Vitreous humor samples were collected from all patients at the time of pars plana vitrectomy surgery immediately before the surgical procedure. Vitreous AREG and PGRN values were determined by the ELISA method. Results: The mean AREG and PGRN values were similar in the groups (p=0.427, p=0.459, respectively). Conclusions: The results demonstrated that vitreous AREG and PGRN levels have no significant relationship with proliferative diabetic retinopathy.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-10270amphiregulinprogranulinvitreousdiabetes mellitusproliferative diabetic retinopathy |
| spellingShingle | Burak BILGIN Mete GULER Hulya CICEK Selma URFALIOGLU Gokhan KOKUSARI Bedia MARANGOZOGLU SAHIN Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin Medeniyet Medical Journal amphiregulin progranulin vitreous diabetes mellitus proliferative diabetic retinopathy |
| title | Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin |
| title_full | Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin |
| title_fullStr | Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin |
| title_full_unstemmed | Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin |
| title_short | Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin |
| title_sort | searching for biomarkers in proliferative diabetic retinopathy amphiregulin and progranulin |
| topic | amphiregulin progranulin vitreous diabetes mellitus proliferative diabetic retinopathy |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-10270 |
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