30-hydroxygambogic acid increases the efficacy of cisplatin in an HPV+ head and neck cancer in vivo model

30-hydroxygambogic acid increases the efficacy of cisplatin in an HPV+ head and neck cancer in vivo model

Abstract Background Head and neck squamous cell carcinoma (HNSCC) affects more than half a million people annually, and nearly 80% of oropharyngeal cancer cases are caused by human papillomavirus (HPV). Current treatments include chemo- and radiotherapy, though the effectiveness of these therapies i...

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Bibliographic Details
Main Authors: Sonia N. Whang, Valeria Rodarte, Trevor Lohman, Josh Barforough, Lennox Chitsike, Gina N. Lucas, David Lee, Caleb Ruiz-Jimenez, Yan Chen Wongworawat, Rouba Ali-Fehmi, Marya Wahidi, Juli Unternaehrer, Valery Filippov, Penelope J. Duerksen-Hughes
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Human papillomavirus (HPV)
Head and neck cancer
Head and neck squamous cell carcinoma (HNSCC)
30-hydroxygambogic acid (GA-OH)
HPV+ mouse xenograft
Combination therapy
Online Access:https://doi.org/10.1186/s12885-025-14638-3
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