Integrative habitat analysis and multi-instance deep learning for predictive model of PD-1/PD-L1 immunotherapy efficacy in NSCLC patients: a dual-center retrospective study

Integrative habitat analysis and multi-instance deep learning for predictive model of PD-1/PD-L1 immunotherapy efficacy in NSCLC patients: a dual-center retrospective study

Abstract Background PD-1/PD-L1 immunotherapy represents the primary treatment for advanced NSCLC patients; however, response rates to this therapy vary among individuals. This dual-center study aimed to integrate habitat radiomics and multi-instance deep learning to predict durable clinical benefits...

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Bibliographic Details
Main Authors: Xiaoxiao Huang, Xiaoxin Huang, Yurun Xie, Kui Wang, Housheng Bai, Ruiling Ning, Xiqi Zhu, Deyou Huang, Guanqiao Jin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medical Imaging
Subjects:
Non-small cell lung cancer
Immunotherapy
Deep learning
Multiple instance learning
Habitat analysis
PD-L1 expression
Online Access:https://doi.org/10.1186/s12880-025-01828-5
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