Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation
Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active soluble forms; serum levels of these molecules may thereby reflect the functional...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2014/404096 |
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| _version_ | 1832561444763205632 |
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| author | Roald Lindås Tor Henrik Andersson Tvedt Kimberley Joanne Hatfield Håkon Reikvam Øystein Bruserud |
| author_facet | Roald Lindås Tor Henrik Andersson Tvedt Kimberley Joanne Hatfield Håkon Reikvam Øystein Bruserud |
| author_sort | Roald Lindås |
| collection | DOAJ |
| description | Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active soluble forms; serum levels of these molecules may thereby reflect the functional status of endothelial cells. Furthermore, acute GVHD is an inflammatory reaction and endothelial cells function as local regulators of inflammation. We therefore investigated whether differences in preconditioning/pretransplant serum levels of endothelium-expressed molecules (i.e., endocan, vascular cell adhesion molecule 1 (VCAM-1), and E-selectin) were associated with a risk of posttransplant GVHD. Our study should be regarded as a population-based study of consecutive and thereby unselected patients (n=56). Analysis of this pretreatment endothelium biomarker profile by unsupervised hierarchical clustering identified a subset of patients with increased early nonrelapse mortality. Furthermore, low endocan levels were significantly associated with acute GVHD in the liver and gastrointestinal tract, whereas high VCAM-1 levels were associated with acute GVHD in the skin only. Our study suggests that the preconditioning/pretransplant status of endothelial cells (possibly through altered trafficking of immunocompetent cells) is important for the risk and the organ involvement of later acute GVHD. |
| format | Article |
| id | doaj-art-9dff82aec6c942b2963460712740d8b0 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-9dff82aec6c942b2963460712740d8b02025-02-03T01:24:56ZengWileyJournal of Transplantation2090-00072090-00152014-01-01201410.1155/2014/404096404096Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell TransplantationRoald Lindås0Tor Henrik Andersson Tvedt1Kimberley Joanne Hatfield2Håkon Reikvam3Øystein Bruserud4Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, NorwaySection for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, NorwaySection for Hematology, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwaySection for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, NorwaySection for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayEndothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active soluble forms; serum levels of these molecules may thereby reflect the functional status of endothelial cells. Furthermore, acute GVHD is an inflammatory reaction and endothelial cells function as local regulators of inflammation. We therefore investigated whether differences in preconditioning/pretransplant serum levels of endothelium-expressed molecules (i.e., endocan, vascular cell adhesion molecule 1 (VCAM-1), and E-selectin) were associated with a risk of posttransplant GVHD. Our study should be regarded as a population-based study of consecutive and thereby unselected patients (n=56). Analysis of this pretreatment endothelium biomarker profile by unsupervised hierarchical clustering identified a subset of patients with increased early nonrelapse mortality. Furthermore, low endocan levels were significantly associated with acute GVHD in the liver and gastrointestinal tract, whereas high VCAM-1 levels were associated with acute GVHD in the skin only. Our study suggests that the preconditioning/pretransplant status of endothelial cells (possibly through altered trafficking of immunocompetent cells) is important for the risk and the organ involvement of later acute GVHD.http://dx.doi.org/10.1155/2014/404096 |
| spellingShingle | Roald Lindås Tor Henrik Andersson Tvedt Kimberley Joanne Hatfield Håkon Reikvam Øystein Bruserud Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation Journal of Transplantation |
| title | Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation |
| title_full | Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation |
| title_fullStr | Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation |
| title_full_unstemmed | Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation |
| title_short | Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation |
| title_sort | preconditioning serum levels of endothelial cell derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation |
| url | http://dx.doi.org/10.1155/2014/404096 |
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