Monte carlo simulation of heterotypic cell aggregation in nonlinear shear flow

Monte carlo simulation of heterotypic cell aggregation in nonlinear shear flow

In this paper, we develop a population balance model for cell aggregationand adhesion process in a nonuniform shear flow. Some Monte Carlosimulation results based on the model are presented for the heterotypic cell-cellcollision and adhesion to a substrate under dynamic shear forces. In particular,w...

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Bibliographic Details
Main Authors: Jiakou Wang, Margaret J. Slattery, Meghan Henty Hoskins, Shile Liang, Cheng Dong, Qiang Du
Format: Article
Language:English
Published: AIMS Press 2006-07-01
Series:Mathematical Biosciences and Engineering
Subjects:
tumor metastasis
cell aggregation
numerical simulation
nonlinear shear flow
population balance model
parallel plate flow chamberexperiments.
smolu-chowski equation
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.683
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Summary:In this paper, we develop a population balance model for cell aggregationand adhesion process in a nonuniform shear flow. Some Monte Carlosimulation results based on the model are presented for the heterotypic cell-cellcollision and adhesion to a substrate under dynamic shear forces. In particular,we focus on leukocyte (PMN)-melanoma cell emboli formation and subsequenttethering to the vascular endothelium (EC) as a result of cell-cell aggregation.The simulation results are compared with the results of experimental measurement.Discussions are made on how we could further improve the accuracy ofthe population balance type modelling.
ISSN:1551-0018

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