Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals
Spermatogonial stem cells (SSCs) are the germline stem cells that are essential for the maintenance of spermatogenesis in the testis. However, it has not been sufficiently understood in amphibians, reptiles, and fish because numerous studies have been focused mainly on mammals. The aim of this revie...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/4755514 |
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| author | Hyuk Song Hyun-Jung Park Won-Young Lee Kyung Hoon Lee |
| author_facet | Hyuk Song Hyun-Jung Park Won-Young Lee Kyung Hoon Lee |
| author_sort | Hyuk Song |
| collection | DOAJ |
| description | Spermatogonial stem cells (SSCs) are the germline stem cells that are essential for the maintenance of spermatogenesis in the testis. However, it has not been sufficiently understood in amphibians, reptiles, and fish because numerous studies have been focused mainly on mammals. The aim of this review is to discuss scientific ways to elucidate SSC models of nonmammals in the context of the evolution of testicular organization since rodent SSC models. To further understand the SSC models in nonmammals, we point out common markers of an SSC pool (undifferentiated spermatogonia) in various types of testes where the kinetics of the SSC pool appears. This review includes the knowledge of (1) common molecular markers of vertebrate type A spermatogonia including putative SSC markers, (2) localization of the markers on the spermatogonia that have been reported in previous studies, (3) highlighting the most common markers in vertebrates, and (4) suggesting ways of finding SSC models in nonmammals. |
| format | Article |
| id | doaj-art-9dc6f890e86344448fa6ba9fde469131 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9dc6f890e86344448fa6ba9fde4691312025-02-03T01:06:36ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/4755514Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in NonmammalsHyuk Song0Hyun-Jung Park1Won-Young Lee2Kyung Hoon Lee3Department of Stem Cell and Regenerative TechnologyDepartment of Animal BiotechnologyDepartment of Animal ScienceDepartment of Stem Cell and Regenerative TechnologySpermatogonial stem cells (SSCs) are the germline stem cells that are essential for the maintenance of spermatogenesis in the testis. However, it has not been sufficiently understood in amphibians, reptiles, and fish because numerous studies have been focused mainly on mammals. The aim of this review is to discuss scientific ways to elucidate SSC models of nonmammals in the context of the evolution of testicular organization since rodent SSC models. To further understand the SSC models in nonmammals, we point out common markers of an SSC pool (undifferentiated spermatogonia) in various types of testes where the kinetics of the SSC pool appears. This review includes the knowledge of (1) common molecular markers of vertebrate type A spermatogonia including putative SSC markers, (2) localization of the markers on the spermatogonia that have been reported in previous studies, (3) highlighting the most common markers in vertebrates, and (4) suggesting ways of finding SSC models in nonmammals.http://dx.doi.org/10.1155/2022/4755514 |
| spellingShingle | Hyuk Song Hyun-Jung Park Won-Young Lee Kyung Hoon Lee Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals Stem Cells International |
| title | Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals |
| title_full | Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals |
| title_fullStr | Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals |
| title_full_unstemmed | Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals |
| title_short | Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals |
| title_sort | models and molecular markers of spermatogonial stem cells in vertebrates to find models in nonmammals |
| url | http://dx.doi.org/10.1155/2022/4755514 |
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