Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China
BackgroundPlasma beta-amyloid (Aβ) are important biomarkers for Alzheimer’s disease and cognitive impairment (CI), but results are controversial. It remains unclear whether hypertension modulates their relationship. This cross-sectional study investigates whether hypertension moderates the relations...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1532676/full |
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| author | Ziyu Liu Yaoli He Simeng Cui Liangjun Dang Binyan Zhang Jin Wang Wenhui Lu Kang Huo Yu Jiang Chen Chen Ling Gao Shan Wei Yi Zhao Ningwei Hu Jingyi Wang Hong Lv Hong Lv Qiumin Qu Qiumin Qu Suhang Shang |
| author_facet | Ziyu Liu Yaoli He Simeng Cui Liangjun Dang Binyan Zhang Jin Wang Wenhui Lu Kang Huo Yu Jiang Chen Chen Ling Gao Shan Wei Yi Zhao Ningwei Hu Jingyi Wang Hong Lv Hong Lv Qiumin Qu Qiumin Qu Suhang Shang |
| author_sort | Ziyu Liu |
| collection | DOAJ |
| description | BackgroundPlasma beta-amyloid (Aβ) are important biomarkers for Alzheimer’s disease and cognitive impairment (CI), but results are controversial. It remains unclear whether hypertension modulates their relationship. This cross-sectional study investigates whether hypertension moderates the relationship between plasma Aβ and cognitive impairment (CI).MethodsThis cross-sectional study included 1488 subjects ≥ 40 years from rural areas of northwestern China. CI was defined as a Mini-Mental State Examination score lower than the cutoff. Firstly, plasma Aβ40, Aβ42, Aβ42/Aβ40 were analyzed as restricted cubic spline. Then, categories of combined plasma Aβ were created by making bisection of plasma Aβ according to average and combining them as L-Aβ40 and L-Aβ42, H-Aβ40 and L-Aβ42, L-Aβ40 and H-Aβ42, H-Aβ40 and H-Aβ42. Decreased plasma Aβ40 was defined as < 25th percentile. Multivariate logistic regression examined the relationship between plasma Aβ and CI in total population, the hypertension subgroup and the non-hypertension subgroup.Results737 participants (49.5%) had hypertension and 189 participants (12.7%) had CI. Simultaneously elevated plasma Aβ40 and Aβ42 was associated with CI in hypertension (H-Aβ40 and H-Aβ42 vs. L-Aβ40 and L-Aβ42, 21.1% vs.10.7%, P = 0.033; OR = 1.984 [95% CI, 1.067–3.691], P = 0.030) but not in the non-hypertension. Decreased plasma Aβ40 was associated with CI in the non-hypertension (14.9% vs. 9.2%, P = 0.026; OR = 1.728 [95% CI, 1.018–2.931], P = 0.043) but not in the hypertension.ConclusionHypertension is an important modulator in the relationship between plasma Aβ and CI. Simultaneously elevated plasma Aβ40 and Aβ42 in the hypertension, and decreased plasma Aβ40 in the non-hypertension, may be risk factors for CI. These findings emphasize the need to consider hypertension in CI detection. |
| format | Article |
| id | doaj-art-9dc6343744bc46e9942f96dbccb1919c |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-9dc6343744bc46e9942f96dbccb1919c2025-01-28T06:41:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011710.3389/fnagi.2025.15326761532676Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, ChinaZiyu Liu0Yaoli He1Simeng Cui2Liangjun Dang3Binyan Zhang4Jin Wang5Wenhui Lu6Kang Huo7Yu Jiang8Chen Chen9Ling Gao10Shan Wei11Yi Zhao12Ningwei Hu13Jingyi Wang14Hong Lv15Hong Lv16Qiumin Qu17Qiumin Qu18Suhang Shang19Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, Baoji Central Hospital, Baoji, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, Huyi Hospital of Traditional Chinese Medicine, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDevelopment and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaCenter for Brain Science, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaBackgroundPlasma beta-amyloid (Aβ) are important biomarkers for Alzheimer’s disease and cognitive impairment (CI), but results are controversial. It remains unclear whether hypertension modulates their relationship. This cross-sectional study investigates whether hypertension moderates the relationship between plasma Aβ and cognitive impairment (CI).MethodsThis cross-sectional study included 1488 subjects ≥ 40 years from rural areas of northwestern China. CI was defined as a Mini-Mental State Examination score lower than the cutoff. Firstly, plasma Aβ40, Aβ42, Aβ42/Aβ40 were analyzed as restricted cubic spline. Then, categories of combined plasma Aβ were created by making bisection of plasma Aβ according to average and combining them as L-Aβ40 and L-Aβ42, H-Aβ40 and L-Aβ42, L-Aβ40 and H-Aβ42, H-Aβ40 and H-Aβ42. Decreased plasma Aβ40 was defined as < 25th percentile. Multivariate logistic regression examined the relationship between plasma Aβ and CI in total population, the hypertension subgroup and the non-hypertension subgroup.Results737 participants (49.5%) had hypertension and 189 participants (12.7%) had CI. Simultaneously elevated plasma Aβ40 and Aβ42 was associated with CI in hypertension (H-Aβ40 and H-Aβ42 vs. L-Aβ40 and L-Aβ42, 21.1% vs.10.7%, P = 0.033; OR = 1.984 [95% CI, 1.067–3.691], P = 0.030) but not in the non-hypertension. Decreased plasma Aβ40 was associated with CI in the non-hypertension (14.9% vs. 9.2%, P = 0.026; OR = 1.728 [95% CI, 1.018–2.931], P = 0.043) but not in the hypertension.ConclusionHypertension is an important modulator in the relationship between plasma Aβ and CI. Simultaneously elevated plasma Aβ40 and Aβ42 in the hypertension, and decreased plasma Aβ40 in the non-hypertension, may be risk factors for CI. These findings emphasize the need to consider hypertension in CI detection.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1532676/fullbeta-amyloidcognitive impairmenthypertensionAlzheimer’s diseasea cross-sectional study |
| spellingShingle | Ziyu Liu Yaoli He Simeng Cui Liangjun Dang Binyan Zhang Jin Wang Wenhui Lu Kang Huo Yu Jiang Chen Chen Ling Gao Shan Wei Yi Zhao Ningwei Hu Jingyi Wang Hong Lv Hong Lv Qiumin Qu Qiumin Qu Suhang Shang Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China Frontiers in Aging Neuroscience beta-amyloid cognitive impairment hypertension Alzheimer’s disease a cross-sectional study |
| title | Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China |
| title_full | Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China |
| title_fullStr | Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China |
| title_full_unstemmed | Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China |
| title_short | Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China |
| title_sort | hypertension moderates the relationship between plasma beta amyloid and cognitive impairment a cross sectional study in xi an china |
| topic | beta-amyloid cognitive impairment hypertension Alzheimer’s disease a cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1532676/full |
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